The cell cycle as a therapeutic target for Alzheimer's disease

RL Neve, DL McPhie - Pharmacology & therapeutics, 2006 - Elsevier
… state of tau and therefore are candidate targets for therapeutic intervention in AD. … peptides
that accumulate in the brains of patients with Alzheimer's disease (AD). The primacy of APP in …

[PDF][PDF] A therapeutic intervention for Alzheimer's disease using ginsenoside Rg3: Its role in M2 microglial activation and non-amyloidogenesis

JW Ahn, SK Jang, BR Jo, HS Kim, JY Park… - J. Physiol …, 2021 - jpp.krakow.pl
… for treating Alzheimer’s disease as a new therapeutic intervention. Key words: Alzheimer’s
disease, ginsenoside … Panax ginseng enhances cognitive performance in Alzheimer disease. …

Mitochondrial dysfunction in Alzheimer's disease: Role in pathogenesis and novel therapeutic opportunities

JM Perez Ortiz, RH Swerdlow - British journal of pharmacology, 2019 - Wiley Online Library
… (n = 1) as therapeutic interventions. Table 2 lists some characteristics of these trials. The
metabolic intermediate OAA listed in this table is being tested by our group in a Phase 1b trial (…

Mitochondrial dysfunction: different routes to Alzheimer's disease therapy

P Picone, D Nuzzo, L Caruana… - Oxidative medicine …, 2014 - Wiley Online Library
… Moreover, we analyze how these vulnerable points for Aβ-mediated mitochondrial dysfunction
may be distinctive and perhaps complementary therapeutic intervention targets for AD. …

Development of a multicomponent intervention to prevent Alzheimer's disease

S Saito, Y Yamamoto, M Ihara - Frontiers in neurology, 2019 - frontiersin.org
Alzheimer's Disease (AD) in several epidemiologic investigations. It is now widely accepted
that cerebrovascular disease … and pharmacological therapeutic approaches for AD treatment…

Cerebrovascular contributions to Alzheimer's disease pathophysiology and potential therapeutic interventions in mouse models

LAM Thomason, B Stefanovic… - European Journal of …, 2013 - Wiley Online Library
… The inter-relationship between vascular dysfunction and Alzheimer's disease pathology …
Alzheimer's disease and cerebrovascular amyloid angiopathy. We will also discuss therapeutic

Epidemiological findings of vascular risk factors in Alzheimer's disease: implications for therapeutic and preventive intervention

C Qiu - Expert review of neurotherapeutics, 2011 - Taylor & Francis
… -inflammatory therapies) have generally failed to prove to be efficacious preventive or therapeutic
… when designing preventive or therapeutic intervention against the dementing disorder. …

[HTML][HTML] AD “Statin”: Alzheimer's disorder is a “fast” disease preventable by therapeutic intervention initiated even late in life and reversible at the early stages

V Volloch, BR Olsen, S Rits - Annals of integrative molecular …, 2020 - ncbi.nlm.nih.gov
The present study posits that Alzheimer’s disorder is a “fast” disease. This is in sharp
contrast to a view, prevailing until now, that Alzheimer’s Disease (AD) is a quintessential “slow” …

Therapy for Alzheimer's disease: Missing targets and functional markers?

M Stoiljkovic, TL Horvath, M Hajós - Ageing research reviews, 2021 - Elsevier
… Existing drugs provide only short-term symptomatic benefits, while the development of
effective disease-modifying therapeutic interventions that would prevent, halt, or reverse AD …

The glucagon-like peptides: a new genre in therapeutic targets for intervention in Alzheimer's disease

TA Perry, NH Greig - Journal of Alzheimer's disease, 2002 - content.iospress.com
… the potential of GLP-1 and analogs as novel therapeutic targets for intervention in Alzheimer's
disease (AD) and potentially other central and peripheral neurodegenerative conditions. …