[HTML][HTML] The number of trait loci in late-onset Alzheimer disease
EW Daw, H Payami, EJ Nemens, D Nochlin… - The American Journal of …, 2000 - cell.com
… in the genetics of late-onset Alzheimer disease (AD), evidence exists … We estimated the
number of additional quantitative-trait loci and … We found evidence that four additional loci make a …
number of additional quantitative-trait loci and … We found evidence that four additional loci make a …
PM20D1 is a quantitative trait locus associated with Alzheimer's disease
… We find that PM20D1 is a methylation and expression quantitative trait locus coupled to an
AD-risk associated haplotype, which displays enhancer-like characteristics and contacts the …
AD-risk associated haplotype, which displays enhancer-like characteristics and contacts the …
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease
… evidence suggesting an initiation of disease in the entorhinal cortex and … Alzheimer's Disease
Neuroimaging Initiative and the AddNeuroMed study. To identify genetic susceptibility loci …
Neuroimaging Initiative and the AddNeuroMed study. To identify genetic susceptibility loci …
Interpretation of risk loci from genome-wide association studies of Alzheimer's disease
… list of SNPs associated with Alzheimer's disease across GWAS, … GWAS evidence at different
loci for Alzheimer's disease, and … expression; quantitative trait locus studies are generally …
loci for Alzheimer's disease, and … expression; quantitative trait locus studies are generally …
[HTML][HTML] Longitudinal data in peripheral blood confirm that PM20D1 is a quantitative trait locus (QTL) for Alzheimer's disease and implicate its dynamic role in disease …
Background While Alzheimer’s disease (AD) remains one of the most challenging diseases
to tackle, genome-wide genetic/epigenetic studies reveal many disease-associated risk loci, …
to tackle, genome-wide genetic/epigenetic studies reveal many disease-associated risk loci, …
[HTML][HTML] Multi-trait association studies discover pleiotropic loci between Alzheimer's disease and cardiometabolic traits
… risk factors that are shared between Alzheimer’s disease (AD) and other traits, ie, pleiotropy,
… (GTEx) project expression quantitative trait loci (eQTL) to identify candidate causal genes. …
… (GTEx) project expression quantitative trait loci (eQTL) to identify candidate causal genes. …
Fine mapping of the α-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
N Ertekin-Taner, J Ronald, H Asahara… - Human molecular …, 2003 - academic.oup.com
… intermediate, quantitative phenotype for late onset Alzheimer's disease (LOAD), we previously
obtained … Together, these two studies provide strong evidence for a novel LOAD locus on …
obtained … Together, these two studies provide strong evidence for a novel LOAD locus on …
[HTML][HTML] Cell-type-specific expression quantitative trait loci associated with Alzheimer disease in blood and brain tissue
Because regulation of gene expression is heritable and context-dependent, we investigated
AD-related gene expression patterns in cell types in blood and brain. Cis-expression …
AD-related gene expression patterns in cell types in blood and brain. Cis-expression …
[HTML][HTML] Brain APOE expression quantitative trait loci-based association study identified one susceptibility locus for Alzheimer's disease by interacting with APOE ε4
… Nevertheless, no study reported interactions of expression quantitative trait locus (eQTL)
for APOE with APOE genotype. In present study, we included 9286 unrelated AD patients and …
for APOE with APOE genotype. In present study, we included 9286 unrelated AD patients and …
Fine mapping of the MAPT locus using quantitative trait analysis identifies possible causal variants in Alzheimer's disease
SM Laws, P Friedrich, J Diehl-Schmid, J Müller… - Molecular …, 2007 - nature.com
… In addition to senile plaques, neurofibrillary tangles are characteristic of Alzheimer's disease
(AD… The H1c haplotype at the MAPT locus is associated with Alzheimer's disease. Hum Mol …
(AD… The H1c haplotype at the MAPT locus is associated with Alzheimer's disease. Hum Mol …
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