Health effects of ambient particulate matter—biological mechanisms and inflammatory responses to in vitro and in vivo particle exposures

KL Maier, F Alessandrini, I Beck-Speier… - Inhalation …, 2008 - Taylor & Francis
… the clear evidence showing that ultrafine particulate matter triggers inflammatory mechanisms
that may play a role in chronic pulmonary inflammation. Particle surface area and the …

The innate and adaptive immune response induced by alveolar macrophages exposed to ambient particulate matter

R Miyata, SF van Eeden - Toxicology and applied pharmacology, 2011 - Elsevier
… dioxides, nitrogen oxides) or particulate (eg, PM). A main theme of this review is to provide
the basic feature of AM immune responses to primary outdoor particulates, and thus, it is …

Systemic response to ambient particulate matter: relevance to chronic obstructive pulmonary disease

SF van Eeden, A Yeung, K Quinlam… - Proceedings of the …, 2005 - atsjournals.org
… In the present review, we provide evidence for the systemic inflammatory response induced
by exposure to atmospheric particles and cigarette smoke with particular reference to its …

Involvement of TLR2 and TLR4 in inflammatory immune responses induced by fine and coarse ambient air particulate matter

J Shoenfelt, RJ Mitkus, R Zeisler… - Journal of leukocyte …, 2009 - academic.oup.com
… to ambient air particulate matter has been suggested to be a key factor in the pathogenesis
of inflammatory … However, receptors and mechanisms underlying these responses have not …

The effects of ambient particulate matter on human alveolar macrophage oxidative and inflammatory responses

K Sawyer, S Mundandhara, AJ Ghio… - Journal of Toxicology …, 2009 - Taylor & Francis
… , eventually producing inflammation-induced injury. Our results indicate ambient PM may
also suppress oxidative and inflammatory responses in healthy AM when PM exposure …

Cytokines Involved in the Systemic Inflammatory Response Induced by Exposure to Particulate Matter Air Pollutants (PM10)

SF van EEDEN, WC Tan, T Suwa, H Mukae… - American journal of …, 2001 - atsjournals.org
… In summary, our results show that AM that phagocytoses ambient particulate matter result in
a dose-dependent increase in TNF-α production and that particles with different composition …

Pro‐inflammatory response and oxidative stress induced by specific components in ambient particulate matter in human bronchial epithelial cells

L Yang, G Liu, Z Lin, Y Wang, H He, T Liu… - Environmental …, 2016 - Wiley Online Library
… A lot of studies have shown that PM2.5 exposure promotes inflammation in the lung which
is associated with a systemic inflammatory response. Oxidative stress and inflammation have …

Systemic inflammatory response induced by particulate matter air pollution: the importance of bone-marrow stimulation

SF Eeden, JC Hogg - … of Toxicology and Environmental Health, Part …, 2002 - Taylor & Francis
… to ambient particulate matter air pollution induces a systemic inflammatory response that …
In this review we provide evidence for the systemic inflammatory response induced by …

Linking ambient particulate matter pollution effects with oxidative biology and immune responses

FJ Kelly, JC Fussell - Annals of the New York Academy of …, 2015 - Wiley Online Library
… in this paper, linking the health effects of ambient, combustion-related PM pollution with
oxidative biology and immune responses, are revealing the underlying biological mechanisms …

Murine pulmonary inflammatory responses following instillation of size-fractionated ambient particulate matter

CAJ Dick, P Singh, M Daniels, P Evansky… - Journal of toxicology …, 2003 - Taylor & Francis
… ., 1998), and these responses can be inhibited with the antioxidant N-acetylcysteine, suggesting
that the actual signaling of the inflammatory response is dependent on oxidative stress. …