METHODS This points to consider statement was informed by a review of the literature and
current guidelines. Resources consulted included PubMed and relevant American College of …

… American College of Medical Genetics and Genomics (ACMG), American Society of Clinical
Oncology, and College of … kinase pathway, resulting in acquired resistance to BRAF inhibitor …

… , reproducibility, and robustness data that assess the analytical performance of the assay
and account for specimen integrity, which can be affected by the method and time of acquisition…

… A copy number variant (CNV) is defined as a segment of … microarray results, the American
College of Medical Genetics (… These guidelines do not apply to CNVs representing acquired …

… variants. … the American College of Medical Genetics and Genomics (ACMG) and the Cancer
Genomics Consortium (CGC). In the following sections, we first describe the types of variants …

… of acquired somatic and germline genetic variants in the … relevance of a variant (eg,
distinguishing a driver variant that is … of American Pathologists (CAP), and American College of …

… tested in the routine clinical setting for variants in 30 genes associated with TAAD or 174 …
the performance of variant classification based on recommendations of American College of …

… To assist clinical laboratories in the classification and reporting of CNVs, irrespective of the
technology used to identify them, the American College of Medical Genetics and Genomics …

… for variant classification in solid tumors when using the 2017 Association for Molecular
Pathology/American Society of Clinical Oncology/College of American … the American College of …

… transparency in the interpretation of acquired CNVs and CN-… variants detected by CMA
clinical testing. The resulting framework will include a process for classifying acquired variants …