… Isosteric replacement of amide groups is a classic practice in medicinal chemistry. This digest
… medicinal chemists an overview of the usefulness of these amide isosteres in drug design. …

… bioisosteres from either a synthetic or biological perspective. We review a broad range of
amide bioisosteres … In this context, we have categorized amide bioisosteres into 13 categories: …

… d, One of the most common reactions in medicinal chemistry is amide coupling. This
reaction couples carboxylic acids with amines to form amides, often using powerful coupling …

… classical isosteres, ensuring its relevance to medicinal chemistry. … is the first definition of
most relevance to medicinal chemistry. … Amide isosteres are generally introduced to modulate …

… In summary, 120 reduced amide isosteres were screened using a high throughput in situ …
in ‘click’ chemistry-based drug discovery of reduced amide inhibitors for other proteases. …

… chemistry. The sulfonamide functional group represents one of the most important amide
isosteres in … Sulfonamide-containing compounds have been widely used in medicinal chemistry …

… 1,5-Disubstituted 1,2,3-triazoles (1,5-Tz) are considered bioisosteres of cis-amide bonds. …
This study illustrates that substitution of amides by 1,5-disubstituted 1,2,3-triazoles is an …

… After amide 11 was prepared, synthesis of amide 12 was relatively straightforward because
… the desired amide framework (27), and MOM hydrolysis gave the final target, amide 12, in …

… amide can be replaced with a bioisosteric 1,3,4-oxadiazole with improved potency. Here, we
report a further study of amide … Collectively, our medicinal chemistry efforts have resulted in …

… Thus a 1,2,3-triazole-bearing cyxlotetrapeptide in which a 1,2,3-triaozle was used as an
amide isostere was obtained via Cu(I)-catalyzed alkyne–azide cycloaddition with an excellent …