AmpC β-lactamases

GA Jacoby - Clinical microbiology reviews, 2009 - Am Soc Microbiol
… The first bacterial enzyme reported to destroy penicillin was the AmpC β-lactamase of …
resistance was then designated ampC. ampA strains overproduced β-lactamase, suggesting a …

AmpC β-lactamases: what do we need to know for the future?

ND Hanson - Journal of Antimicrobial Chemotherapy, 2003 - academic.oup.com
… to distinguish between ESBL and plasmid-encoded AmpC β-lactamase producers do we
run the risk of the emergence of extended-spectrum AmpC β-lactamases (ESACs)?31 With that …

Review of carbapenemases and AmpC-beta lactamases

FJ Marsik, S Nambiar - The Pediatric infectious disease journal, 2011 - journals.lww.com
β-lactamases (ESBLs), AmpC β-lactamases (AmpC-BL), Klebsiella pneumoniae carbapenemases
(KPC), and the metallo-β-lactamases (… due to carbapenemases and AmpC-BL using …

A primer on AmpC β-lactamases: necessary knowledge for an increasingly multidrug-resistant world

PD Tamma, Y Doi, RA Bonomo… - Clinical Infectious …, 2019 - academic.oup.com
AmpC production and β-lactam resistance, even for infections caused by initially susceptible
isolates. The risk of inducing AmpC production varies by β-lactam and … AmpC β-lactamase–…

AmpC β-lactamase-producing Enterobacterales: what a clinician should know

S Meini, C Tascini, M Cei, E Sozio, GM Rossolini - Infection, 2019 - Springer
… Resistance to third-generation cephalosporins is typical of MDRs, being mainly due to
the production of extended spectrum β-lactamases or AmpC-type β-lactamases. …

Plasmid-determined AmpC-type β-lactamases

A Philippon, G Arlet, GA Jacoby - Antimicrobial agents and …, 2002 - Am Soc Microbiol
The predominant mechanism for resistance to-lactam antibiotics in gram-negative bacteria is
the synthesis of-lactamase. To meet this challenge,-lactams with greater-lactamase stability…

Extended-spectrum-β-lactamase, AmpC, and carbapenemase issues

KS Thomson - Journal of clinical microbiology, 2010 - Am Soc Microbiol
… screen for plasmid-mediated AmpC β-lactamases (28). Alternatively, … AmpC β-lactamases,
plasmid-mediated AmpC β-lactamases are most accurately detected with the multiplex AmpC

Nanomolar inhibitors of AmpC β-lactamase

F Morandi, E Caselli, S Morandi, PJ Focia… - Journal of the …, 2003 - ACS Publications
β-lactams to the original substrates has allowed resistance to develop further. Broad-spectrum
β-lactamases, such as the class C β-lactamase AmpC, … class A β-lactamases, leading to …

Controversies about extended-spectrum and AmpC beta-lactamases.

KS Thomson - Emerging Infectious Diseases, 2001 - ncbi.nlm.nih.gov
… To date, all plasmidmediated AmpC beta-lactamases have … Both ESBLs and plasmid-mediated
AmpC beta-lactamases are … for ESBLs in the presence of an AmpC beta-lactamase. …

AmpC Disk Test for Detection of Plasmid-Mediated AmpC β-Lactamases in Enterobacteriaceae Lacking Chromosomal AmpC β-Lactamases

JA Black, ES Moland, KS Thomson - Journal of clinical …, 2005 - Am Soc Microbiol
… -mediated AmpC β-lactamases in isolates that lack a chromosomally encoded AmpC β-lactamase. …
gene but only produces an insignificant amount of AmpC β-lactamase) were used. …