AMPK activation: a therapeutic target for type 2 diabetes?

KA Coughlan, RJ Valentine… - … syndrome and obesity …, 2014 - Taylor & Francis
… This paper will review the regulation of the AMPK pathway … AMPK’s role and dysregulation
in T2D, the currently known activators of AMPK, and the potential for a direct AMPK activator

The emerging role of AMPK in the regulation of breathing and oxygen supply

AM Evans, AD Mahmoud, J Moral-Sanz… - Biochemical …, 2016 - portlandpress.com
… Whichever we consider, it is now evident that AMPK may be key to the regulation of vascular
reactivity during metabolic stress [23,142] and may thus facilitate gaseous exchange across …

Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling

RA Sinha, BK Singh, J Zhou, Y Wu, BL Farah, K Ohba… - Autophagy, 2015 - Taylor & Francis
regulated by mitochondrial activity via production of ROS and activation of CAMKK2 and
PRKAA1/AMPK … PRKAA1/AMPK substrate, ULK1, was a prerequisite for mitochondrial targeting …

AMPK is mitochondrial medicine for neuromuscular disorders

AI Mikhail, SY Ng, SR Mattina, V Ljubicic - Trends in Molecular Medicine, 2023 - cell.com
… Here, we survey mitochondrial stresses that are common … or pharmacological AMPK
activation to enhance mitochondrial … the role of AMPK in regulating mitochondrial quality control; (…

AMPK in health and disease

GR Steinberg, BE Kemp - Physiological reviews, 2009 - journals.physiology.org
… This experiment provides a link between AMPK activation and the regulation of L-PK, but
future studies are required to determine whether this relationship is also observed in vivo in …

AMP-activated protein kinase signaling in metabolic regulation

YC Long, JR Zierath - The Journal of clinical investigation, 2006 - Am Soc Clin Investig
… Conversely, AMPK activation causes TORC2 phosphorylation … upstream kinase of AMPK)
abolishes AMPK activation and leads … , AMPK action has been implicated in regulation of liver …

Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics

Z Chen, C Lei, C Wang, N Li, M Srivastava… - Nature …, 2019 - nature.com
… To further explore the potential mechanism of ARMC10 function in mitochondrial regulation,
we performed an interactome study of this protein by using a BioID technique 36 . We …

AMP‐activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives

B Viollet, B Guigas, J Leclerc, S Hébrard… - Acta …, 2009 - Wiley Online Library
… of AMPK in hepatic energy metabolism and this review provides a general overview of AMPK
regulation, … AMPK activation in the liver by overexpression of AMPK-CA or by the use of the …

Mitophagy: molecular mechanisms, new concepts on parkin activation and the emerging role of AMPK/ULK1 axis

R Iorio, G Celenza, S Petricca - Cells, 2021 - mdpi.com
… the molecular mechanisms that regulate mitochondrial removal and … AMPK and mitochondrial
biology, we also highlight recent advances in the role of the AMPK/ULK1 axis in regulating

[HTML][HTML] Regulation of AMPK by the ubiquitin proteasome system

M Zungu, JC Schisler, MF Essop, C McCudden… - The American journal of …, 2011 - Elsevier
… and hypertrophy, causing an increase in AMPK activity that can be viewed as … regulation
of AMPK activity by kinases, recent studies have introduced the concept that AMPK is regulated