Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons
Y Peng, J Liu, L Shi, Y Tang, D Gao… - Journal of …, 2016 - Wiley Online Library
… , we confirmed that mannitol did not induce mitochondrial dysfunction, insulin resistance,
and AMPK inactivation as the same level of glucose did (Figure S2). This is in agreement with …
and AMPK inactivation as the same level of glucose did (Figure S2). This is in agreement with …
[HTML][HTML] Mitochondrial dysfunction induces the invasive phenotype, and cell migration and invasion, through the induction of AKT and AMPK pathways in lung cancer …
SY Han, YJ Jeong, Y Choi… - International …, 2018 - spandidos-publications.com
… the correlation between mitochondrial dysfunction and epithelial‑… mitochondrial dysfunction
on EMT and migration in lung cancer cells were investigated using inhibitors of mitochondrial …
on EMT and migration in lung cancer cells were investigated using inhibitors of mitochondrial …
Role of AMPK-mediated adaptive responses in human cells with mitochondrial dysfunction to oxidative stress
SB Wu, YT Wu, TP Wu, YH Wei - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
… stress induced by mitochondrial dysfunction. We suggest that AMPK may be a potential
target for the development of therapeutic agents for the treatment of mitochondrial diseases. …
target for the development of therapeutic agents for the treatment of mitochondrial diseases. …
[HTML][HTML] Mitochondrial dysfunction activates the AMPK signaling and autophagy to promote cell survival
… mitochondria. Our results demonstrate that AMPK and autophagy senses mitochondria
dysfunction and … Our findings may provide new insights into the interplay between mitochondria …
dysfunction and … Our findings may provide new insights into the interplay between mitochondria …
… /Metabolomics‐Based Validation of AMPK and PI3K/AKT Signaling Pathway as a Central Role of Shengqi Fuzheng Injection Regulation of Mitochondrial Dysfunction …
W Guo, S Liu, X Zheng, Z Xiao, H Chen… - Oxidative Medicine …, 2021 - Wiley Online Library
… ameliorate muscle cell mitochondrial function by activating AMPK and inhibiting the PI3K/Akt
signaling pathways, and the expression changes of mitochondrial metabolic enzymes …
signaling pathways, and the expression changes of mitochondrial metabolic enzymes …
The anti-malarial atovaquone selectively increases chemosensitivity in retinoblastoma via mitochondrial dysfunction-dependent oxidative damage and Akt/AMPK …
F Ke, J Yu, W Chen, X Si, X Li, F Yang, Y Liao… - … and biophysical research …, 2018 - Elsevier
… of mitochondrial dysfunction, our work provides clear details that oxidative stress and damage,
and Akt/AMPK/mTOR … via mitochondrial dysfunction-dependent oxidative damage and …
and Akt/AMPK/mTOR … via mitochondrial dysfunction-dependent oxidative damage and …
Artesunate targets oral tongue squamous cell carcinoma via mitochondrial dysfunction-dependent oxidative damage and Akt/AMPK/mTOR inhibition
Q Xiao, L Yang, H Hu, Y Ke - Journal of bioenergetics and biomembranes, 2020 - Springer
… work demonstrates that inducing mitochondrial dysfunction by anti-… 4-HNE and p-AMPK
whereas decreased p-Akt and p-mTOR in … that artesunate activates AMPK, inhibits Akt/mTOR, …
whereas decreased p-Akt and p-mTOR in … that artesunate activates AMPK, inhibits Akt/mTOR, …
Mitochondrial dysfunction and Parkinson disease: a Parkin–AMPK alliance in neuroprotection
L Hang, J Thundyil, KL Lim - Annals of the New York Academy …, 2015 - Wiley Online Library
… of AMPK and inactivation of Akt following the suppression by these PD toxins.61 Notably,
AMPK and Akt are … Thus, whether AMPK activation is neuroprotective or a neuronal killer in PD …
AMPK and Akt are … Thus, whether AMPK activation is neuroprotective or a neuronal killer in PD …
[HTML][HTML] … through down-regulation of PI3K/Akt/mTOR signaling pathway and up-regulation of ROS-mediated mitochondrial dysfunction in hepatocellular carcinoma …
… In the present study, our data showed that coptisine not only increased the p-AMPK, but also
decreased the phosphorylation of PI3K and Akt. Concurrently, the phosphorylation of mTOR …
decreased the phosphorylation of PI3K and Akt. Concurrently, the phosphorylation of mTOR …
Mitochondrial dysfunction and apoptosis are attenuated through activation of AMPK/GSK-3β/PP2A pathway in Parkinson's disease
J Su, J Zhang, R Bao, C Xia, Y Zhang, Z Zhu… - European Journal of …, 2021 - Elsevier
… that AMPK activation might regulate mitochondrial disorder and … mitochondrial dysfunction
and apoptosis after AMPK activation by Western blot analysis. The expressions of AMPK/GSK-…
and apoptosis after AMPK activation by Western blot analysis. The expressions of AMPK/GSK-…
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