… for control of β-cell function. Here, we show that inhibition of AMPK in β-cells by high glucose
… (mTOR) pathway, another cellular sensor for nutritional conditions. Forced activation of …

… the switch from mTORC1 to AMPK signaling in β cells. To … between mTORC1 and
AMPK signaling in maturing β cells, we … (an mTORC1 inhibitor) or 5-aminoimiazole-4-carboxamide-1-β-…

… β-cells through AMPK activation (D. Wang et al., 2015). These results point to the key role of
AMPK/mTOR … asprosin could inhibit β-cell autophagy via AMPK/mTOR signaling pathway. …

… of beta-cells by liraglutide. … -cell growth and proliferation through an AMPK/mTOR/P70S6K
signaling pathway, and whether it prevents beta-cell glucolipotoxicity associated with mTOR …

… Since ectopic Akt activation could increase beta cell mTOR activity in conditions of AMPK
activation, we examined whether Akt protected the beta cells through this mTOR stimulation. …

… lacking Lkb1 are larger as a consequence of enhanced mTOR activation, presumably
resulting from AMPK deficiency, hypertrophy is not observed in AMPKα1α2 double knockout beta …

… AMPK/mTOR pathway. Representative immunoblot analysis of the phosphorylation of AMPK
and mTOR in RIN-5F cells … ; (c) dosages in presence of AMPK inhibitor ie compound C (10 …

… 1E β-cells with rapamycin increased AMPK phosphorylation (… Moreover, forced expression
of AMPK in β-cells increased … AMPK by inhibition of mTOR/S6K might reduce β-cell mass. …

… hyper-activation of mTORC1 in diabetic islets or β cells under conditions of increased β cell
stress and metabolic demands. These recent findings uncover mTORC1‘s importance as an …

… that AMPK/mTOR pathway is involved in kaempferol-induced autophagy [33]. Thus we intended
to determine whether AMPK/mTOR … In order to confirm the specific involvement of AMPK …