… AMPK activation by SIRT1, two groups reported that AMPK can function as a SIRT1 activator
… Whether Nampt activation is pivotal for SIRT1 activation by AMPK is unclear (cf. Refs. 8 and …

… SIRT1 and AMPK in several metabolic tissues and propose a working model of how the
AMPK-SIRT1 … that specifically activates SIRT1, while AMPK is specifically activated by metformin …

… to activate AMPK and increase mitochondrial function requires SIRT1 in vivo, and whether
SIRT1 … The main impediment to studying SIRT1 in vivo has been the poor survival, impaired …

… In particular, a counter-balancing model involving the cross-talks between SIRT1 and
AMP-activated protein kinase (AMPK), another stress and energy sensor, is suggested for …

… deacetylase activity is driven by NAD + levels 22 , we examined whether AMPK indirectly
activates SIRT1 by altering the intracellular NAD + /NADH ratio. Supporting this hypothesis, …

… Additionally, the result that AMPK inhibitor compound C reversed the resveratrol-induced …
AMPK and SIRT1. Our results provide evidence that resveratrol may activate the AMPK/SIRT1 …

… occur independently of AMP-activated protein kinase (AMPK), an important metabolic … that
SRT1720 activates AMPK in a Sirt1-independent manner and SRT1720 activates AMPK by …

… AMPK activates SIRT1, we next evaluated whether SIRT1 mediates the effects of FGF21 on
mitochondrial function downstream of AMPK. … adenovirus expressing either SIRT1-shRNA or …

… -activated protein kinase (AMPK) and sirtuin 1 (SIRT1) show similarities in modulation of
metabolic pathway, we hypothesized that activation of AMPK and SIRT1 in … of AMPK and SIRT1 …

… activates AMPK and SIRT1 and enhance their signal transduction based on the model:
metformin + leucine → AMPK ↔ SIRT1 → synergistic activation … of the AMPK ↔ SIRT1 network? …