… that amyloid beta (1-42) (Aβ42), the predominant Aβ peptide species in amyloid plaques,
first accumulates in … Recently, we have shown that many (if not most) amyloid plaques in the …

… accumulation of amyloid β 1–42 in Alzheimer’s disease brains, we studied the fate of exogenous
amyloid β 1–42 and its interaction with the α7 receptor … accumulation of amyloid β 1–42 …

… , involves accumulation in the brain of extracellular plaques containing the β-amyloid protein
(… neurons, particularly those expressing nicotinic acetylcholine receptors (nAChRs), thereby …

… α7- nicotinic acetylcholine receptor (nAChR) plays a crucial role in the pathogenesis of
this disease, which is characterized by amyloid-β (Aβ) accumulations and neurofibrillary tangles …

… Activation of muscarinic acetylcholine receptors (mAChRs) … and on the development of
amyloid pathology in a transgenic … Aβ and greater accumulation of amyloid plaque pathology. …

… Nicotinic acetylcholine receptors (nAChRs) expressed in the … disease accompanied by
accumulation of β-amyloid (Aβ 42 ), … and increase of α3β4 nAChRs, accumulation of Aβ 42 and …

… Amyloid accumulation is one of the earliest changes in AD pathology, and this peptide
may cause neuronal death in the CNS. The precise mechanism of Aβ -induced cytotoxicity …

… by the accumulation of extracellular amyloid-β (Aβ) and neurofibrillary tangles formed by …
accumulation of hyperphosphorylated tau. According to the amyloid hypothesis, accumulation …

… – receptor complex providing a potential mechanism for intracellular Abeta accumulation …
interaction may be a mechanism by which amyloid accumulates and deposits in the CNS, in …

… accumulation and toxicity but the cell content remnants may be what is detected as amyloid
… Amyloid peptide activates 7 nicotinic acetylcholine receptors expressed in Xenopus oocytes. …