… The generation of a Tg rat reproducing the full AD-like amyloid pathology has been elusive.
… new transgenic rat line, coded McGill-R-Thy1-APP, developed to express the human amyloid…

… reported transgenic APP overexpressing rat models developed AD-like β-amyloid (Aβ) … In
the present study, we have characterized a transgenic rat model overexpressing transgenes …

… aspects of AD pathology in the rat. Transgenic rat models offer distinctive advantages over
mice. … Intracellular iAβ accumulation was observed in other rat models of amyloid pathology. …

… To examine the evolution of the AD-like amyloid pathology we incubated sections with the
… In 13-month old transgenic rats with advanced amyloid pathology we revealed marked …

… to transgenic approaches to Alzheimer's pathology. … or infusions of AI3 or Alzheimer amyloid
cores into the rat brain (6,12,25,31,… Our recent studies of A[3 infused into the rat brain have …

… We next examined cerebral β-amyloid pathology and Aβ abundance in cohorts of Tg animals
at various ages (6, 15–17, and 25–27 months old) by multiple independent strategies (see …

… Background:Intracellular accumulation of ß -amyloid (A ß ) is one of the early features in the
… and transgenic animal models of the AD-like amyloid pathology. In a transgenic rat model, …

… established that a transgenic rat model expressing … rats intrahippocampally with dilute
Alzheimer brain extracts containing aggregated Aβ. After a 9-month incubation period, these rats …

… Two lines of Sprague Dawley rats with transgenes expressing human amyloid precursor
protein (APP) with the familial AD (FAD) mutations K670N/M671L and K670N/M671L/V717I …

… rat model generated by AAV-mediated gene transfer (the AAV-AD rat) to induce the production
of amyloid … hippocampi and without a significant transgene overexpression. Soluble Aβ42 …