… transcriptase inhibitor–resistant minority variants (MVs) are included in this analysis. To avoid
bias … P value comparison by Cox proportional hazard analysis. Median follow-up time, 31 (…

… Polymorphisms associated with impaired treatment responses that occur in wild-type viruses
should not be used in epidemiologic analyses to identify transmitted HIV-1 drug resistance. …

… DRMs to be surveilled (∼175 in total) based on genotype analyses, phenotypic resistance
tests and clinical outcome in patients on antiretroviral therapies. Primary DRMs directly confer …

… to which drug resistance mutations are missed by standard genotyping methods, we
analyzed the same plasma samples from 26 patients with suspected multidrug-resistant human …

… aimed to determine the patterns of drug resistance against two first line anti-TB drugs (RIF
and INH). We also analyzed the frequency and type of drug resistant mutations in the 81-bp …

… mutations L10F, K45I and I84V arising from exposure to the inhibitor XM323. R8Q was one
of the first drug resistant mutations … the effect of these drug-resistant mutations on the kinetic …

… drug. Further support for this mechanism was obtained by comparing the competitive ratio
of drug to metabolite in drug-resistant mutants with the ratio in the more sensitive parent strain. …

… of drug resistance mutations, we defined nonpolymorphic mutations to be mutations present
… The updated 2009 SDRM list developed in this analysis has 93 mutations including 34 NRTI…

… mutation results in extreme impairment of oseltamivir’s inhibition potency. Our structural
analyses … site while the influence of other studied mutations is much less prominent. Our crystal …

… Furthermore, these studies did not assess the impact of resistance mutations. In our series,
univariate analysis showed that history of protease inhibitor use, but not CD4 cell counts or …