… principal androgens, testosterone and dihydrotestosterone (DHT), are mediated via androgen
receptors (ARs), ligand‐activated transcription factors that belong to the nuclear receptor …

… AR remains important in the development and progression of prostate cancer. AR … cancer
progression, and the majority of androgen-independent or hormone refractory prostate cancers …

… Our present mandate is to apply our knowledge of AR signaling in prostate cancer
progression to the development of more effective therapeutics for prostate cancer patients. …

… of codon 877 mutation in the androgen receptor gene in advanced prostate cancers. …
of the androgen receptor gene and progression of human prostate cancer. Nature Genetics …

… of the androgen receptor in prostate cancer. The CAG and GGN trinucleotide repeats in exon
… of the androgen receptor gene have been linked to prostate cancer risk and progression in …

… of prostate cancer. We defined the androgen receptor pathway by selecting 200 genes
that were androgen responsive in prostate cancer cell lines and/or xenografts. This …

… in the progression to CRPC is essential in developing successful future therapies. This
review provides a synopsis of AR structure and signaling in prostate cancer progression, with a …

… In such cases androgen receptor … which the receptor is thought to remain active is mutation.
This review summarises the present data on androgen receptor mutations in prostate cancer, …

… the 'intracrine' production of androgen Novel approaches to androgen receptor inhibition are
in … through combined inhibition of classic androgen receptor signaling and other interrelated …

… The androgen receptor (AR) plays a key role in progression to incurable androgen
ablation–resistant prostate cancer (PCA). We have identified three novel AR splice variants lacking …