… The clinical implication of these findings is that because they harbor mutations or loss in
the ligand-binding domain, these variants may not be antagonized by any of the currently …

… clinical implications of antiandrogens in the environment. To this end we (a) review the proposed
mechanism(s) whereby androgen receptor (… , and (c) discuss the clinical implications of …

… The androgen receptor (AR) is the key regulatory element of androgen signaling in the cell.
… This review will summarize the most important findings about the AR and the androgen …

ABSTRACT: Androgen receptor (AR) is a member of the steroid hormone receptor family of
molecules. AR primarily is responsible for mediating the physiologic effects of androgens by …

… Abbreviations and accessions for androgen receptor sequences used in this analysis:
androgen receptors from frog (Xenopus laevis, xenAR, U67129), mouse (Mus musculus, musAR, …

… More specifically, this review paper focuses on the androgen receptor (AR) and the multitude
of ways it can become resistant to drugs. We highlight the distinct ways the AR can evade …

… altered androgen receptors might be present in human prostatic tumours. The first androgen
receptor … The frequency of androgen receptor mutations in primary tumours of the prostate is …

… Metastatic castration-resistant prostate cancer (mCRPC) shows a number of adaptive
mechanisms that facilitate continued androgen receptor (AR) dependent tumor growth. In this …

… androgens at initial diagnosis; hence, androgen ablation therapy directed toward a reduction
in serum androgens and the inhibition of androgen receptor … response to androgen ablation …

… Figure 1 Androgen action is exerted through transcriptional regulation by the nuclear
androgen receptor (AR). AR is a ligand-dependent transcription factor. Androgen binding induces …