[HTML][HTML] Androgen receptor as a potential target for treatment of breast cancer

Y Wu, JV Vadgama - International journal of cancer research and …, 2017 - ncbi.nlm.nih.gov
Clinical studies have shown that the androgen receptor (AR) is ubiquitously expressed in
breast cancers and this could provide prognostic implication in the diagnosis and treatment of …

The androgen receptor malignancy shift in prostate cancer

BT Copeland, SK Pal, EC Bolton, JO Jones - The Prostate, 2018 - Wiley Online Library
… malignancy shift, including the DNA-binding patterns that define the shift, the transcriptome
changes associated with the shift, the putative drivers of the shift, and its clinical implications. …

Aging and androgens: Physiology and clinical implications

BD Anawalt, AM Matsumoto - Reviews in Endocrine and Metabolic …, 2022 - Springer
… Estrogen receptor α and androgen receptors are found on kisspeptin neurons, but GnRH …
not have estrogen receptor α and androgen receptors [19]. Although estrogen receptor α has …

Mechanism of androgen receptor action

J Li, F Al-Azzawi - Maturitas, 2009 - Elsevier
… of the androgen receptor, as well as their co-regulators. We also explore several
clinically relevant aspects of the molecular biology of the androgen receptor and its co-regulators. …

Modeling androgen deprivation therapy–induced prostate cancer dormancy and its clinical implications

X Dong, H Xue, F Mo, Y Lin, D Lin, NKY Wong… - Molecular Cancer …, 2022 - AACR
clinical dormant prostate cancer cells and the lack of representative models. In this study, we
aimed to develop clinically … ADT or androgen-receptor inhibitors were included in this study. …

[HTML][HTML] Expression of androgen receptor in breast cancer and its significance as a prognostic factor

Q Yu, Y Niu, N Liu, JZ Zhang, TJ Liu, RJ Zhang… - Annals of oncology, 2011 - Elsevier
Background Breast cancer is an extraordinarily hormone-dependent tumor. This study was
to evaluate androgen receptor (AR) status and its significance in breast cancer in Chinese …

Redefining androgen receptor function: clinical implications in understanding prostate cancer progression and therapeutic resistance

M Paliouras, C Alvarado, M Trifiro - Prostate cancer–Leading …, 2016 - books.google.com
… The current description of the function of the human androgen receptor (AR), as a transcription
factor directing androgen responsive gene expression, is limited in scope and thus is …

A glucocorticoid-responsive mutant androgen receptor exhibits unique ligand specificity: therapeutic implications for androgen-independent prostate cancer

AV Krishnan, XY Zhao, S Swami, L Brive… - …, 2002 - academic.oup.com
… in men are low and may not be clinically significant (17). The role of AR mutations in the
transition of prostate cancers to androgen-independent growth and in the subsequent failure of …

[PDF][PDF] Targeting the androgen receptor in prostate cancer—A resilient foe

PS Nelson - N Engl J Med, 2014 - iacld.com
clinical implications? A … , the androgen receptor in its many permutations still represents
the key target in prostate cancer. Continued efforts directed toward ablating androgen-receptor

Androgen receptors in prostate cancer.

Z Culig, H Klocker, G Bartsch… - Endocrine-related …, 2002 - erc.bioscientifica.com
The androgen receptor (AR), a transcription factor that mediates the action of androgens in
target tissues, is expressed in nearly all prostate cancers. Carcinoma of the prostate is the …