Regulation of androgen receptor levels: implications for prostate cancer progression and therapy
KL Burnstein - Journal of cellular biochemistry, 2005 - Wiley Online Library
… receptor hormone binding domain. Further, upregulation of AR not only allowed cells to
respond to very low levels of androgen … goal of reducing AR levels in advanced prostate cancer. …
respond to very low levels of androgen … goal of reducing AR levels in advanced prostate cancer. …
Molecular biology of the androgen receptor
EP Gelmann - Journal of clinical oncology, 2002 - ascopubs.org
… responsiveness in prostate cancer does not correlate with either the presence or the levels
of androgen receptor in cancer tissues. Furthermore, AR expression persists after the patient …
of androgen receptor in cancer tissues. Furthermore, AR expression persists after the patient …
Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens
KK Waltering, MA Helenius, B Sahu, V Manni, MJ Linja… - Cancer research, 2009 - AACR
… The aim was to investigate whether AR overexpression hypersensitizes cells to the low
levels of androgens, as we have suggested previously (15), as well as to identify the candidate …
levels of androgens, as we have suggested previously (15), as well as to identify the candidate …
Targeting the androgen receptor pathway in prostate cancer
YU Chen, CL Sawyers, HI Scher - Current opinion in pharmacology, 2008 - Elsevier
… When prostate cancers progress following androgen depletion therapy, there are currently …
on androgen receptor (AR) signaling which is reactivated despite low serum androgen levels. …
on androgen receptor (AR) signaling which is reactivated despite low serum androgen levels. …
Low stroma androgen receptor level in normal and tumor prostate tissue is related to poor outcome in prostate cancer patients
P Wikström, J Marusic, P Stattin, A Bergh - The Prostate, 2009 - Wiley Online Library
… Androgens regulate prostate epithelial cell proliferation, differentiation and death, not primarily
by effect on androgen receptors … The role of AR receptors and androgen effects in prostate …
by effect on androgen receptors … The role of AR receptors and androgen effects in prostate …
Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen
CW Gregory, RT Johnson Jr, JL Mohler, FS French… - Cancer research, 2001 - AACR
… The androgen receptor (AR) is highly expressed in androgen-dependent and recurrent … to
the growth response to low levels of androgens in model systems of androgen-dependent and …
the growth response to low levels of androgens in model systems of androgen-dependent and …
The androgen receptor in breast cancer
P Giovannelli, M Di Donato, G Galasso… - Frontiers in …, 2018 - frontiersin.org
… of androgen action in this disease remains a challenging puzzle. Androgen receptor (AR)
is … as well as the relative levels of circulating estrogens and androgens. However, the AR …
is … as well as the relative levels of circulating estrogens and androgens. However, the AR …
Polymorphisms of the androgen receptor gene and the estrogen receptor β gene are associated with androgen levels in women
L Westberg, F Baghaei, R Rosmond… - The Journal of …, 2001 - academic.oup.com
… CAG repeats are associated with low AR responsiveness. In … levels after the administration
of a synthetic androgen (20). In … androgen receptors may influence serum androgen levels in …
of a synthetic androgen (20). In … androgen receptors may influence serum androgen levels in …
A and B forms of the androgen receptor are expressed in a variety of human tissues
CM Wilson, MJ McPhaul - Molecular and cellular endocrinology, 1996 - Elsevier
… androgen receptor (AR) isoform levels in a variety of human fetal tissues. Relative levels
of … androgen receptor (AR) isoform levels in a variety of human adult tissues. Tissues were …
of … androgen receptor (AR) isoform levels in a variety of human adult tissues. Tissues were …
Androgen receptor in prostate cancer
CA Heinlein, C Chang - Endocrine reviews, 2004 - academic.oup.com
… The normal development and maintenance of the prostate is dependent on androgen
acting through the androgen receptor (AR). AR remains important in the development and …
acting through the androgen receptor (AR). AR remains important in the development and …
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