… The androgen receptor (AR) is a steroid receptor transcription factor with functions critical
for normal male development as well as the growth and survival of normal and cancerous …

Androgen receptor splice variants (AR-Vs)—which are expressed in castration-resistant
prostate cancer (CRPC) cell lines and clinical samples—lack the C-terminal ligand-binding …

Context Although a number of studies have demonstrated the importance of constitutively
active androgen receptor variants (AR-Vs) in prostate cancer, questions still remain about the …

… Androgen receptor (AR) is a transcription factor that becomes active upon binding to
androgens via its ligand-binding domain (LBD) or in response to signaling cascades initiated by …

… Androgens mediate the biological effects through the androgen receptor (AR). Given time,
patients with advanced prostate cancer treated with ADT inevitably progress to castration-…

… androgen receptor (AR) … variants is under investigation in several clinical trials. In this
review, we provide an overview of the most relevant AR variants and discuss current AR variant …

… and functionally distinct androgen receptor (AR) splice variants have been decoded and …
splice variants contain a transcribed “intronic” sequence, capable of encoding a short variant-…

… the androgen receptor (AR) and its ligands contribute to the continued growth of androgen-…
(LBD), and generation of AR splice variants that lack the LBD that impede the discovery of …

… The androgen receptor (AR) transcription factor is a master regulator of normal … variants of
the AR gene are expressed in CRPC cells and can be translated to produce AR variant (AR-V) …

… shown that AR variants may require … androgen withdrawal and androgen receptor inhibitor
MVD-3100 treatment, which correlates with our findings herein of an increase in AR variants …