… : The renin–angiotensin system (RAS) and its effector molecule, angiotensin (Ang) II, affect
… in cardiac remodeling and dysfunction in the failing heart. Many of the downstream effects of …

… function of angiotensin II (Ang II) receptors in the human heart, … normal (n = 6) and failing (n
= 14) hearts. Ang II receptors were … mammalian heart Ang II receptors. In normal adult donor …

… ACE inhibitor therapy and our studies show that the heart's major enzymatic pathway for Ang
II formation is not blocked by ACE inhibitors, … benefit of angiotensin in the heart in the face of …

… In the normal heart, locally derived angiotensin II may modulate … heart. The present review
focuses on identification and possible functions of a local RAS in normal and failing hearts…

… Furthermore, in angiotensin II-infused rats, cardiac apelin mRNA was decreased after 24
h … angiotensin II–angiotensin type 1 receptor system directly. Inhibition of the renin–angiotensin …

… 2 -receptor mRNA expression is unchanged in failing human hearts. A similar conclusion
was … membranes prepared from terminally failing and control hearts: in the failing heart, AT 1 -…

… This report describes whether or not a tissue RA system exists in the human heart and to …
hearts. We have also examined the effects of angiotensin iI on collagen synthesis in the heart. …

… The elevated expression of Ang (1–7) in failing heart tissue paralleled the expression of its
… in the expression of ACE2 between failing and non-failing heart. In an experimental model of …

… Total Ang II receptor and AT 1 subtype densities were significantly reduced in failing hearts
as compared with NF hearts, with no significant differences between ICM and DCM hearts (…

… Angiotensin-converting enzyme inhibitors (ACEi) improve cardiac function and remodeling …
heart failure (HF). Blockade of the renin–angiotensin system (RAS) with an angiotensin II type …