… complications, including acute kidney injury, can be fatal. Animal models that correctly mimic
… Too often, however, animal models do not properly mimic human disease. In this Review, …

… In this review, however, we shall focus on animal models of ATN, the most … kidney injury’
(AKI, a term underscoring the often absence of identifiable renal pathology in limited kidney …

… in large animal models. The aim of this review is not to suggest that murine models are not
valid to study AKI. Instead, our objective is to demonstrate that large animal models can serve …

… provide the ability to standardize the injury and collect multi-… overview of what animal models
have taught us about the … of the appropriateness of available AKI animal models. Finally, we …

… Animal models of AKI will play a decisive role in the quest … animal models of AKI, illustrate
some emerging therapeutic approaches identified in recent years by the use of these models, …

… of the pathogenesis of kidney injury that allows the development … Thus, we have focused the
present review on animal models … animal models of acute kidney injury (AKI), chronic kidney …

… models fail to … of model development for AKI due to tubular injury, focusing on the translatability
of discoveries using human kidney organoids, zebrafish, rodent and large animal models …

… work as acute kidney injury, and … animal models of acute kidney injury in this context and
describe their pathophysiological features, as well as their relevance to human disease. Kidney …

… animal models follows different criteria at each of these stages. Initially, target expression and
function are tested in simple models of kidney injury that … to apply animal models that more …

… preclinical animal models. These models include a sterile model of endotoxemia, polymicrobial
sepsis models and single pathogen models. Since the endotoxemia and polymicrobial …