… of ramucirumab, the antagonist monoclonal antibody (mAb) that inhibits VEGFR-2 and has
… We examine in-depth the pre-clinical studies using DC101, the mAb to mouse VEGFR-2, …

… VEGFR2 KDR, anti-KDR monoclonal antibodies were generated by standard hybridoma
technology and by using phage display library. l-ligh affinity antibodies (… VEGFR2 antagonists …

… Here, we employed receptor-specific antagonist antibodies in an orthotopic spontaneous …
for the key role of VEGFR-3 activation in metastasis. Inhibition of VEGFR-3 activation more …

… In this study, the VEGFR2-targeted peptoid as well as … 2, antibodies were produced against
BSA and KLH in all BSA and KLH vaccinated mice, respectively, but anti-GU81 antibodies …

… The absence of similar marked increases in plasma VEGF detected after administration
of various small molecule VEGFR-2 antagonists that we tested suggests an antibody-dependent …

… Using a variety of VEGF mutants that specifically bind VEGFR-1, -2, or -3 and neutralizing
anti-VEGFR-2 antibodies, we have observed that VEGF- and VEGF-C (ΔNΔC) in vitro …

… Instead of relying on antibody associating domains or physical linkage, this work highlights
an approach to creating dual-specific proteins where additional functionality is introduced …

… /2 activation. Our findings reveal a novel role of DCN as an antagonistic ligand for VEGFR-2, …
3C), we used a VEGFR-2 blocking monoclonal antibody recognizing the ligand-binding …

… loading of the gel was confirmed by probing the membrane with the anti-VEGFR2 antibody.
… ligands to a member of the cystine-knot BMP antagonists distinct from VEGFs. Gremlin is …

… Therefore, to further validate the utility of 33C3 as a VEGFR-2 antagonist, the ability to
inhibit tube formation in this assay format was tested (Fig. 4). This assay was modified from …