… and the antagonistic effect of selenium, normal human primary hepatocytes were incubated
… The percentage of apoptotic hepatocytes, the number of cells in S phase, DNA damage in …

… , exhibits functional glucagon antagonism by uncoupling the glucagon … effects of skyrin on
cells transfected with the human glucagon receptor and on isolated rat and human hepatocytes…

… Both variants are able to bind HGF/SF receptor and have partial agonist and antagonist
activity (18, 19, 20, 21, 22, 23). For example, NK2 has no mitogenic effect on hepatocytes but …

… We subsequently tested HGF/NKl for antagonistic activity using hepatocytes in primary culture
(Fig. 5B). HGF/NKl completely antagonizes HGF-induced mitogenic activity with an IBw of …

… Co-culturing of hepatocytes and nonhepatic primary cells from … , human hepatocytes
represent a critical experimental model for drug development, allowing early evaluation of human …

… However, antagonistic effects of ketoconazole towards PXR were demonstrated as well,
because half-maximal inhibitory concentrations IC 50 were significantly lower as compared to …

… Indeed, the sulfonylurea glibenclamide, the antituberculosis compound rifampicin, the
anticancer drug vinblastine, the leukotriene D4 receptor antagonist MK-571, the non-steroidal anti-…

… from a human hepatocellular carcinoma, seems to be a surrogate to primary human hepatocytes
for … At the two highest combinations, antagonistic, additive and synergistic effects on cell …

… interacting with different pathway yielding complementary pharmacological effects) or reduction
of efficacy of a coadministered drug (eg, antagonistic competition for the same receptors)…

… changed back to a Met antagonist by mutations that disrupt the … antagonist activity and
a rational basis for the inherent properties that distinguished between NK1/NK2 agonist/antagonist …