Molecular structure, vibrational spectroscopic analysis (IR & Raman), HOMO-LUMO and NBO analysis of anti-cancer drug sunitinib using DFT method

Ö Mıhçıokur, T Özpozan - Journal of Molecular Structure, 2017 - Elsevier
… ) is one of the oxindole derivatives approved for the treatment of patients with … spectral
characteristics of Sunitinib. In the present work, IR and Raman spectra of Sunitinib is reported both …

Prediction of solubility of sunitinib malate (an anti-cancer drug) in supercritical carbon dioxide (SC–CO2): Experimental correlations and thermodynamic modeling

G Sodeifian, F Razmimanesh, SA Sajadian - Journal of Molecular Liquids, 2020 - Elsevier
… Accordingly, sunitinib is classified as a low-… this anti-cancer drug include fatigue, hypertension,
diarrhea, stomatitis, and hand–foot syndrome. Following the oral administration, sunitinib

Understanding the molecular-based mechanism of action of the tyrosine kinase inhibitor: sunitinib

AC Mena, EG Pulido, C Guillen-Ponce - Anti-cancer drugs, 2010 - journals.lww.com
… used in the early studies to determine whether sunitinib treatment would result in a decrease
in tumor metabolism. Treatment with 50 mg daily of sunitinib for 4 weeks resulted in a more …

Neuroprotective effects of the anticancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders

W Wrasidlo, LA Crews, IF Tsigelny… - British journal of …, 2014 - Wiley Online Library
… Among 12 different compounds, sunitinib inhibited CDK5 with an IC 50 of 4.2 μM. In silico …
, sunitinib fitted 6 of 10 features of the CDK5 pharmacophore. In a cell‐based model, sunitinib

Blocking autocrine VEGF signaling by sunitinib, an anti-cancer drug, promotes embryonic stem cell self-renewal and somatic cell reprogramming

G Chen, X Xu, L Zhang, Y Fu, M Wang, H Gu, X Xie - Cell research, 2014 - nature.com
… Blocking VEGF signaling with sunitinib, an anti-cancer drug and a receptor tyrosine … Sunitinib
facilitates the derivation of mESCs from blastocysts, and the mESCs maintained in sunitinib

Investigation of temperature-responsive tocosomal nanocarriers as the efficient and robust drug delivery system for sunitinib malate anti-cancer drug: effects of MW …

F Razmimanesh, G Sodeifian - Journal of pharmaceutical sciences, 2022 - Elsevier
… robust drug delivery system with improved drug encapsulation efficiency, extended stability,
proper particle size and industrial upscaling for Sunitinib malate anti-cancer drug. … and drug

[PDF][PDF] Study on sunitinib adsorption on graphene surface as an anticancer drug

S Tanreh, A Shameli, E Balali - Journal of Applied Chemical Research, 2018 - sid.ir
drug especially on nervous system as a result of direct injection. In this work, adsorption of
Sunitinib … These complexes can be appropriate nano-carrier for anti-cancer drug of Sunitinib. …

Actinometric and Φ-order photodegradation properties of anti-cancer Sunitinib

M Maafi, LY Lee - Journal of Pharmaceutical and Biomedical Analysis, 2015 - Elsevier
… The anti-cancer drug was however found to be thermally stable in methanol in the dark [3],
[8], [9]. Despite Z-SUT recognised photodegradation, a number of studies did not report on …

Sunitinib as an anti-endometriotic agent

MA Abbas, AM Disi, MO Taha - European Journal of Pharmaceutical …, 2013 - Elsevier
… So, based on these facts and similarities between endometriosis and cancer, the effect of
the anti-cancer drug sunitinib on peritoneal endometriosis was studied after producing it …

Molecular basis of hypertension side effects induced by sunitinib

G Aparicio-Gallego, FJ Afonso-Afonso… - … -Cancer Drugs, 2011 - journals.lww.com
… This study shows the vascular complications of treatment with a TKI, sunitinib (SU11248), …
treatment with sunitinib in metastatic RCC [ 13 ]. Drug-related hypertension can occur with drug