… Among them, DNA topoisomerase I inhibitors based on Camptothecins and analogues
were found to be potent antiTrypanosoma cruzi agents in micromolar range [10, 11]. …

… Imidazolidine derivatives were studied as anti-Trypanosoma cruzi agents. Imidazolines
can be considered as ethylenediamine/carbonyl precursors and therefore interfere with the …

… as a trypanocidaL agent [61]. In an in vitro assay with Y strain of T. cruzi tryY pomastigote …
38 nΜ to 1.84 μΜ, so these derivatives are aLso considered potentiaL antiparasitic agents …

… The protozoan hemoflagellate Trypanosoma cruzi is the etiologic agent responsible for
Chagas disease. The disease is a so-called “neglected disease” because health markets in …

We modified the thiazolidinic ring at positions N3, C4, and C5, yielding compounds 6–24.
Compounds with a phenyl at position N3, 15–19, 22–24, exhibited better inhibitory properties …

Synthetic thiosemicarbazones and semicarbazones were evaluated for their Trypanosoma
cruzi trypomastigotes obtained from LLC-MK2 cell cultures. In general, thiosemicarbazone …

Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma cruzi.
Currently, only nitroheterocyclic nifurtimox (NFX) and benznidazole (BNZ) are available for …

… The present work reports on the synthesis, anti-Trypanosoma cruzi activities and docking
studies of a novel series of 2-(pyridin-2-yl)-1,3-thiazoles derived from 2-pyridine …

In the search for new therapeutic tools against Chagas’ disease (American Trypanosomiasis)
two series of new platinum(II) complexes with bioactive 5-nitrofuryl containing …

In the present work, we synthesized a series of thiosemicarbazones derived from 1-indanones
with good anti-Trypanosoma cruzi activity. Most of them displayed remarkable …