… In such conditions, administration of higher doses can … treatment outcomes of clinical trials
that were conducted to test the efficacy of administration of high dose of anti-tuberculosis drugs…

… It is likely that higher doses of ethambutol would be associated with higher antibacterial effect,
but the dose-related ocular toxicity of the drug precludes such practice. For isoniazid, dose …

… Prospects for further shortening of treatment rest with the introduction of higher dosage
with rifamycins and with new anti-tuberculosis drugs. These new drugs include the 8 …

… In a phase II randomised, placebo-controlled, multinational clinical trial in patients with
MDR-TB, delamanid administered for 2 months at two different drug doses (100 and 200 mg twice …

… Whatever the reasons, prescribing anti-tuberculosis drugs incorrectly results in drug dosages
being frequently too high or too low, and this should be discouraged. District TB officers …

… 2 h post-dose drug concentrations (C2h) for first-line drugs and 12 studies that reported
clinical outcomes. We pooled data by study quality, design, region, dosing modality and patient …

… Robust and physiologically relevant infection models are required to investigate
pharmacokinetic–pharmacodynamic (PK/PD) correlations for anti-tuberculosis agents at preclinical …

… Dosages of anti-tuberculosis (TB) drugs are recommended to be adjusted according to renal
function for … However, the efficacy and safety outcomes of such renal function-based dosage …

… In conclusion, our study confirms the good tolerability of the WHO-recommended increased
anti-tuberculosis drug dosage in children, especially with regard to the risk of hepatotoxicity, …

… dosing anti-tuberculosis drugs according to ideal body weight and provide dosing caps for
most first-line agents. … of weight on the pharmacokinetics of first-line anti-tuberculosis drugs. …