Overview of anti-tuberculosis (TB) drugs and their resistance mechanisms

R Shi, N Itagaki, I Sugawara - Mini reviews in medicinal …, 2007 - ingentaconnect.com
… resistance can also develop through alterations or overexpression of the INH drug target
InhA, and 0 to 5% of INH-resistant M. tuberculosis isolates have mutations in the inhA open …

Novel solid forms of the anti-tuberculosis drug, Isoniazid: Ternary and polymorphic cocrystals

S Aitipamula, ABH Wong, PS Chow, RBH Tan - CrystEngComm, 2013 - pubs.rsc.org
… We also report ternary cocrystals of INH, INH·NA·SA and INH·NA·FA. All the solid forms
are thoroughly characterized by spectroscopic, X-ray diffraction and thermal techniques. In …

Anti-tuberculosis activity of lipophilic isoniazid derivatives and their interactions with first-line anti-tuberculosis drugs

T Parumasivam, HSN Kumar, P Ibrahim… - journal of pharmacy …, 2013 - Elsevier
… for synthesis of INH-C16, INH-C17 and INH-C18 respectively, followed by … INH-C16,
INH-C17 and INH-C18 were chemically synthesized by augmenting the amine side chain of INH

Towards a new tuberculosis drug: pyridomycin–nature's isoniazid

RC Hartkoorn, C Sala, J Neres, F Pojer… - … molecular medicine, 2012 - embopress.org
antituberculosis agent isoniazid. However, most interestingly, no cross resistance was
observed between pyridomycin and isoniazid, … most frequently encountered isoniazid‐resistant …

Rifampicin-resistant Mycobacterium tuberculosis: susceptibility to isoniazid and other anti-tuberculosis drugs

EV Kurbatova, JS Cavanaugh, NS Shah… - … of tuberculosis and …, 2012 - ingentaconnect.com
… RMP-resistant TB, INH susceptibility may correlate with susceptibility to other antituberculosis
drugs, and this knowledge might help in planning more effective treatment regimens. Our …

Eco-friendly disposal of expired anti-tuberculosis drug isoniazid and its role in the protection of metal

AK Singh, AK Pandey, P Banerjee, SK Saha… - Journal of …, 2019 - Elsevier
Isoniazid with different 5-substituted indole-3-carboxaldehyde. Thus, this study offers eco-friendly
and economical disposal of expired drug isoniazid … earlier studied isoniazid derivatives …

[HTML][HTML] Computational approach to understanding the mechanism of action of isoniazid, an anti-TB drug

L Jena, P Waghmare, S Kashikar, S Kumar… - International journal of …, 2014 - Elsevier
… This INH intermediate in the presence of NADH forms INH-NAD adduct which inhibits inhA
(… Isoniazid is used in conjunction with other effective anti-tuberculosis agents under multi-drug

Isoniazid metal complex reactivity and insights for a novel anti-tuberculosis drug design

EHS Sousa, LA Basso, DS Santos… - JBIC Journal of …, 2012 - Springer
… Here, we investigated the reactivity of isoniazid metal complexes as prototypes for novel
self… isoniazid or (isoniazid)pentacyanoferrate(II) complex resulted in similar oxidized isoniazid

Docking and molecular dynamic study of isoniazid derivatives as anti-tuberculosis drug candidate

R Mardianingrum, SRN Endah, E Suhardiana… - Chemical Data …, 2021 - Elsevier
… ppm, isoniazid derivatives with an MIC of 6.9 μM, and the N-(Disubstitutedbenzoyl)Isoniazid
So, recently we have designed and computational study some isoniazid derivatives to be …

Cucurbituril-resisted acylation of the anti-tuberculosis drug isoniazid via a supramolecular strategy

H Cong, CR Li, SF Xue, Z Tao, QJ Zhu… - Organic & biomolecular …, 2011 - pubs.rsc.org
isoniazid (INH) and the chemical structures of INH, cucurbiturils Q[6] and Q[7], acetyl coenzyme
A and acylating agents. … thioester groups that are used to convey the acetyl group to INH. …