… Current antibiotics are losing efficacy and new antimicrobial … natural products of animal,
bacterial, fungal and plant origin are reviewed in this paper. Their activity against drug-resistant …

… resistome, provides a framework to understand how and why resistance … resistance and
probe the long-term efficacy of new drugs. The origins and evolution of antibiotic resistance …

… of antibiotics to exploit every source of resistance genes and … of resistance for each and
every antibiotic introduced into … salient aspects of antibiotic resistance development over the …

… INTRODUCTION Antibiotic resistance was to occur when a drug loses its ability to inhibit …
clinically relevant antibiotic resistant pathogens are capable of DNA uptake and natural …

… of human influence and natural origins. To our … natural origins and recent human influence.
This study provides a significant reference regarding the global reach of antibiotic resistance, …

… of antibiotics. This article explores the origin of antibiotics and the subsequent emergence
of antibiotic resistance. It delves into the mechanisms employed by bacteria to develop …

… antibiotic resistance is therefore of interest to clinicians, evolutionary biologists and ecologists.
The origin of antibiotic resistance … the origin, spread and evolution of antibiotic resistance …

… Investigations of antibiotic resistance from an environmental … relevant antibiotic‐resistant
bacterial pathogens. It is clear that the environmental microbiota, even in apparently antibiotic‐…

… Origins of resistance genes The origins of antibiotic resistance genes are obscure
because at the time that antibiotics were introduced the biochemical and molecular basis of …

… However, due to HGT and the facile acquisition of new genetic material in these organisms,
these studies do not provide insight into the sources and origins of antibiotic resistance. In …