[HTML][HTML] Noisy response to antibiotic stress predicts subsequent single-cell survival in an acidic environment

K Mitosch, G Rieckh, T Bollenbach - Cell systems, 2017 - cell.com
… cross-protecting stress responses are triggered by different antibiotics we developed a …
expression in response to antibiotic treatment at high time-resolution. We used the antibiotics TMP…

Antibiotics disrupt coordination between transcriptional and phenotypic stress responses in pathogenic bacteria

PA Jensen, Z Zhu, T van Opijnen - Cell reports, 2017 - cell.com
… To identify links between the phenotypic and transcriptional stress response networks,
we examined the response to nutrient depletion, a stressor that has significantly shaped the …

Customized regulation of diverse stress response genes by the multiple antibiotic resistance activator MarA

NA Rossi, MJ Dunlop - PLoS Computational Biology, 2017 - journals.plos.org
… We quantified transmitted noise and our results show good agreement with the theoretical
prediction based on the slope of the fitted Hill function (Fig 1E). In contrast to P micF , P inaA …

Tunable Stochastic Pulsing in the Escherichia coli Multiple Antibiotic Resistance Network from Interlinked Positive and Negative Feedback Loops

J Garcia-Bernardo, MJ Dunlop - PLoS computational biology, 2013 - journals.plos.org
response when stressors are sensed. Here, we develop a stochastic model of the multiple
antibiotic … the Reduced Noise system only in fluctuating, non-constant stress environments, …

Escherichia coli can survive stress by noisy growth modulation

O Patange, C Schwall, M Jones, C Villava… - Nature …, 2018 - nature.com
… Here, we show how noisy expression of a key stress-response … we report here, to survive
antibiotic treatment 2,3 . Our data … Exposure to antibiotics can enhance subsequent survival …

Mechanisms of bacterial persistence during stress and antibiotic exposure

A Harms, E Maisonneuve, K Gerdes - Science, 2016 - science.org
… Though the physical structure of biofilms shields the bacterial community from hostile conditions,
including immune responses, many antibiotics readily penetrate into the biofilm core (11…

Competition sensing: the social side of bacterial stress responses

DM Cornforth, KR Foster - Nature Reviews Microbiology, 2013 - nature.com
antibiotics are frequently upregulated by stress responses to nutrient limitation and cell damage
but very rarely upregulated by stress responses to heat or osmotic stress… But in this noisy

Gene expression tradeoffs determine bacterial survival and adaptation to antibiotic stress

JC Kratz, S Banerjee - PRX Life, 2024 - APS
… ) of antibiotics as a function of the environment in response to replication-… noise in gene
expression, antibiotic import, and damage removal. As such, we choose to coarse grain the noise

Plasmid-mediated phenotypic noise leads to transient antibiotic resistance in bacteria

JCR Hernandez-Beltran, J Rodríguez-Beltrán… - Nature …, 2024 - nature.com
antibiotic resistance genes in clinical bacteria, can rapidly amplify genes, leading to
plasmid-mediated phenotypic noise and transient antibiotic … showing that stress response

Bacterial stress responses as potential targets in overcoming antibiotic resistance

J Dawan, J Ahn - Microorganisms, 2022 - mdpi.com
antibiotic resistance in bacteria. Therefore, this review discusses bacterial stress responses
linked to antibiotic … on novel therapies targeting bacterial stress responses that have been …