Spatially addressed combinatorial protein libraries for recombinant antibody discovery and optimization
H Mao, JJ Graziano, TMA Chase, CA Bentley… - Nature …, 2010 - nature.com
… addressed compound libraries as in small-molecule discovery. Here we apply the latter
strategy to antibody discovery, using a library of ∼10,000 human germline antibody Fabs …
strategy to antibody discovery, using a library of ∼10,000 human germline antibody Fabs …
Selecting and screening recombinant antibody libraries
HR Hoogenboom - Nature biotechnology, 2005 - nature.com
… antibody libraries, the methods for selecting and screening different types of libraries, several
antibody … finally, the impact of library-based approaches on antibody humanization, with a …
antibody … finally, the impact of library-based approaches on antibody humanization, with a …
ALTHEA Gold Libraries™: antibody libraries for therapeutic antibody discovery
P Valadon, SM Pérez-Tapia, RS Nelson… - MAbs, 2019 - Taylor & Francis
… antibodies, and have successfully been used to build antibody phage-displayed libraries. …
using these scaffolds, antibodies discovered via ALTHEA Gold Library™ would perform well …
using these scaffolds, antibodies discovered via ALTHEA Gold Library™ would perform well …
Phage antibody display libraries: a powerful antibody discovery platform for immunotherapy
A Zhao, MR Tohidkia, DL Siegel… - Critical reviews in …, 2016 - Taylor & Francis
… libraries of peptides/proteins and discovery of new recombinant therapeutics. Expression of
proteins such as monoclonal antibodies (… biopannings), phage antibody libraries (PALs) from …
proteins such as monoclonal antibodies (… biopannings), phage antibody libraries (PALs) from …
Evolution of phage display libraries for therapeutic antibody discovery
Y Zhang - MAbs, 2023 - Taylor & Francis
… libraries can be designed for either antibody discovery or engineering. The design of the latter
is based on one parental antibody … antibody phage display libraries for antibody discovery …
is based on one parental antibody … antibody phage display libraries for antibody discovery …
Integrating high‐throughput screening and sequencing for monoclonal antibody discovery and engineering
C Parola, D Neumeier, ST Reddy - Immunology, 2018 - Wiley Online Library
… practice to discover monoclonal antibodies by immunizing … of antibody repertoires that
occur following immunization may offer a means to augment the monoclonal antibody discovery …
occur following immunization may offer a means to augment the monoclonal antibody discovery …
Next-generation antibody discovery platforms
G Hardiman - Proceedings of the National Academy of …, 2012 - National Acad Sciences
… The sequence information provides valuable insights into the selection process and thereby
has the potential to greatly improve library design and quality of antibody repertoires (5). …
has the potential to greatly improve library design and quality of antibody repertoires (5). …
Deep sequencing of phage display libraries to support antibody discovery
U Ravn, G Didelot, S Venet, KT Ng, F Gueneau… - Methods, 2013 - Elsevier
… Antibody discovery process by phage display and possible applications of NGS. In a classical
approach, a library of antibody fragments displayed on phage is used in multiple selection …
approach, a library of antibody fragments displayed on phage is used in multiple selection …
Design of synthetic antibody libraries
I Benhar - Expert opinion on biological therapy, 2007 - Taylor & Francis
… of antibody libraries and attempts to predict the future impact of antibody libraries on drug
discovery. … and application as tool for antibody discovery and optimization. The design of an …
discovery. … and application as tool for antibody discovery and optimization. The design of an …
Antibody discovery: sourcing of monoclonal antibody variable domains
WR Strohl - Current drug discovery technologies, 2014 - ingentaconnect.com
… -rat hybrid IgG antibody), six are mouse-human chimeric antibodies, and … antibodies have
originated from human antibody genes, three isolated from phage libraries of human antibody …
originated from human antibody genes, three isolated from phage libraries of human antibody …
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