Spatially addressed combinatorial protein libraries for recombinant antibody discovery and optimization

H Mao, JJ Graziano, TMA Chase, CA Bentley… - Nature …, 2010 - nature.com
… addressed compound libraries as in small-molecule discovery. Here we apply the latter
strategy to antibody discovery, using a library of ∼10,000 human germline antibody Fabs …

Selecting and screening recombinant antibody libraries

HR Hoogenboom - Nature biotechnology, 2005 - nature.com
antibody libraries, the methods for selecting and screening different types of libraries, several
antibody … finally, the impact of library-based approaches on antibody humanization, with a …

ALTHEA Gold Libraries™: antibody libraries for therapeutic antibody discovery

P Valadon, SM Pérez-Tapia, RS Nelson… - MAbs, 2019 - Taylor & Francis
antibodies, and have successfully been used to build antibody phage-displayed libraries. …
using these scaffolds, antibodies discovered via ALTHEA Gold Library™ would perform well …

Phage antibody display libraries: a powerful antibody discovery platform for immunotherapy

A Zhao, MR Tohidkia, DL Siegel… - Critical reviews in …, 2016 - Taylor & Francis
libraries of peptides/proteins and discovery of new recombinant therapeutics. Expression of
proteins such as monoclonal antibodies (… biopannings), phage antibody libraries (PALs) from …

Evolution of phage display libraries for therapeutic antibody discovery

Y Zhang - MAbs, 2023 - Taylor & Francis
libraries can be designed for either antibody discovery or engineering. The design of the latter
is based on one parental antibodyantibody phage display libraries for antibody discovery

Integrating high‐throughput screening and sequencing for monoclonal antibody discovery and engineering

C Parola, D Neumeier, ST Reddy - Immunology, 2018 - Wiley Online Library
… practice to discover monoclonal antibodies by immunizing … of antibody repertoires that
occur following immunization may offer a means to augment the monoclonal antibody discovery

Next-generation antibody discovery platforms

G Hardiman - Proceedings of the National Academy of …, 2012 - National Acad Sciences
… The sequence information provides valuable insights into the selection process and thereby
has the potential to greatly improve library design and quality of antibody repertoires (5). …

Deep sequencing of phage display libraries to support antibody discovery

U Ravn, G Didelot, S Venet, KT Ng, F Gueneau… - Methods, 2013 - Elsevier
Antibody discovery process by phage display and possible applications of NGS. In a classical
approach, a library of antibody fragments displayed on phage is used in multiple selection …

Design of synthetic antibody libraries

I Benhar - Expert opinion on biological therapy, 2007 - Taylor & Francis
… of antibody libraries and attempts to predict the future impact of antibody libraries on drug
discovery. … and application as tool for antibody discovery and optimization. The design of an …

Antibody discovery: sourcing of monoclonal antibody variable domains

WR Strohl - Current drug discovery technologies, 2014 - ingentaconnect.com
… -rat hybrid IgG antibody), six are mouse-human chimeric antibodies, and … antibodies have
originated from human antibody genes, three isolated from phage libraries of human antibody