The immune diversity in a test tube-non-immunised antibody libraries and functional variability in defined protein scaffolds
E Soderlind, R Carlsson… - … Chemistry & High …, 2001 - ingentaconnect.com
… The aim of all antibody fragment phage library constructions is to display as much functional
variability as … The first type of variability was based on ra nd omisation of preexisting …
variability as … The first type of variability was based on ra nd omisation of preexisting …
High affinity, developability and functional size: the holy grail of combinatorial antibody library generation
D Ponsel, J Neugebauer, K Ladetzki-Baehs, K Tissot - Molecules, 2011 - mdpi.com
… display technology for the generation of human antibodies, a variety of selection methods …
the quality of the antibody library. Concurrent evolution of the libraries has allowed display and …
the quality of the antibody library. Concurrent evolution of the libraries has allowed display and …
Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire
J Glanville, W Zhai, J Berka, D Telman… - Proceedings of the …, 2009 - National Acad Sciences
… ) presents significant length and sequence variability, we find a … , the total diversity of the
antibody library obtained from a human … library construction, and productive germline usages in …
antibody library obtained from a human … library construction, and productive germline usages in …
Design of synthetic antibody libraries
I Benhar - Expert opinion on biological therapy, 2007 - Taylor & Francis
… -approved therapeutic antibodies, one was isolated from an antibody library and many more
… history of antibody libraries and attempts to predict the future impact of antibody libraries on …
… history of antibody libraries and attempts to predict the future impact of antibody libraries on …
Selecting and screening recombinant antibody libraries
HR Hoogenboom - Nature biotechnology, 2005 - nature.com
… antibody libraries, the methods for selecting and screening different types of libraries, several
antibody … finally, the impact of library-based approaches on antibody humanization, with a …
antibody … finally, the impact of library-based approaches on antibody humanization, with a …
Machine learning optimization of candidate antibody yields highly diverse sub-nanomolar affinity antibody libraries
… successful library are improvements over the initial candidate scFv. By comparing a library’s
… method’s ability to explore tradeoffs between library success and diversity. Results of our …
… method’s ability to explore tradeoffs between library success and diversity. Results of our …
A fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favorable biophysical properties
T Tiller, I Schuster, D Deppe, K Siegers, R Strohner… - MAbs, 2013 - Taylor & Francis
… antibodies with excellent biophysical properties were isolated. Our results confirm that quality
can be built into an antibody library by … -H3 length variability observed in the library prior to …
can be built into an antibody library by … -H3 length variability observed in the library prior to …
Parameters and determinants of responses to selection in antibody libraries
… antibody libraries based on distinct scaffolds but harboring the same diversity at randomized
sites. We first show that the response to selection of an antibody library may … the variability of …
sites. We first show that the response to selection of an antibody library may … the variability of …
[HTML][HTML] Generation, diversity determination, and application to antibody selection of a human naive Fab library
… In addition, we validated the antibody library by selecting specific Fabs against 10 different
… in our antibody library differs from that of other natural antibody libraries published so far. …
… in our antibody library differs from that of other natural antibody libraries published so far. …
[HTML][HTML] Discovery of diverse and functional antibodies from large human repertoire antibody libraries
LJ Schwimmer, B Huang, H Giang, RL Cotter… - Journal of …, 2013 - Elsevier
… antibody libraries for the discovery of new therapeutics. We have constructed naïve antibody
phage display libraries … and vector backbones, limiting the variability between the libraries. …
phage display libraries … and vector backbones, limiting the variability between the libraries. …
相关搜索
- synthetic antibody libraries
- phage display antibody libraries
- human antibody libraries
- combinatorial antibody library
- recombinant antibody libraries
- functional variability immune diversity
- antibody libraries cdr sequences
- antibody libraries drug and target discovery
- antibody libraries consensus frameworks
- antibody libraries machine learning optimization
- affinity maturation antibody library
- antibody libraries determinants of responses
- antibody libraries phenotype information
- antibody libraries optimal design features
- antibody libraries immune system
- functional antibody repertoire