Type I IFN-dependent antibody response at the basis of sex dimorphism in the outcome of COVID-19

L Gabriele, A Fragale, G Romagnoli, S Parlato… - Cytokine & Growth …, 2021 - Elsevier
… -α-mediated B cell activation and differentiation into antibody-producing … type I IFN (IFN-I)
signaling occurs more effectively in females, for inducing neutralizing antibody response as an …

Type I IFN enhances follicular B cell contribution to the T cell–independent antibody response

CL Swanson, TJ Wilson, P Strauch… - Journal of Experimental …, 2010 - rupress.org
… facilitate this response by inducing type I interferon (IFN), … the IgG2c antibody response
requires B cell–autonomous IFN-α … enhance TI-2 antibody responses by promoting participation …

Type I IFN signaling on both B and CD4 T cells is required for protective antibody response to adenovirus

J Zhu, X Huang, Y Yang - The Journal of Immunology, 2007 - journals.aai.org
… In this study, we found that type I IFNs were also rapidly … type I IFN receptor (IFNR −/− ), we
showed that type I IFNs were critical for the activation of subsequent adaptive B cell response

Neutralizing type I IFN antibodies trigger an IFN-like response in endothelial cells

HP Moll, H Freudenthaler, A Zommer… - The Journal of …, 2008 - journals.aai.org
… counteract IFN-α or IFN-β activity triggered an “IFN-like” response … factor IFN-stimulated gene
factor 3 and the expression of IFN-… to enhance rather than inhibit type I IFN signals, and the …

Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN

A Le Bon, C Thompson, E Kamphuis… - The Journal of …, 2006 - journals.aai.org
… as direct targets of IFN-αβ during IFN-α-mediated augmentation of the Ab response against
a soluble protein Ag. Strikingly, the ability of IFN-α to stimulate the Ab response and induce …

[HTML][HTML] Role of type I interferon (IFN) in the respiratory syncytial virus (RSV) immune response and disease severity

DR Hijano, LD Vu, LM Kauvar, RA Tripp… - Frontiers in …, 2019 - frontiersin.org
… are known to suppress type I IFN production and a robust type I IFN response to RSV does
… of type I IFNs are associated with mild symptoms in infants and administration of IFN-α prior …

Modulation of T‐cell function by type I interferon

DF Tough - Immunology and cell biology, 2012 - Wiley Online Library
… stimulation of the antibody response was presumed to reflect a requirement for T cell IFN-α/…
+ T cell help for antibody production, as the antibody response to the antigen utilised was …

Immunosuppressive effects of lymphocyte (type II) and leucocyte (type I) interferon on primary antibody responses in vivo and in vitro.

JL Virelizier, EL Chan, AC Allison - Clinical and Experimental …, 1977 - ncbi.nlm.nih.gov
… We have tested the hypothesis that type II interferon (IF), released by immune lymphocytes
… showed a very intense suppression of antibody response to sheep erythrocytes. Sera …

Regulation of type I interferon responses

LB Ivashkiv, LT Donlin - Nature Reviews Immunology, 2014 - nature.com
… -induced suppression of translation and its role in antiviral responses has been reviewed
97 ; here we focus on how translational regulation affects the type I IFN response by …

A phase 1b clinical trial evaluating sifalimumab, an anti-IFN-α monoclonal antibody, shows target neutralisation of a type I IFN signature in blood of dermatomyositis …

BW Higgs, W Zhu, C Morehouse, WI White… - Annals of the …, 2014 - ard.bmj.com
… -IFN-α monoclonal antibody (MI-CP151), we report here the clinical utility of the type I IFN
We also examined the effects of sifalimumab on pathways downstream of type I IFN. Finally, …