… distinct modes of action, which are dependent on ROS generation. This review will focus on
… a novel Topo II inhibitor as well as its distinguished anticancer activity in different systems. …

… As shown in Table 2, only compounds (27) and (28) exhibited significant inhibitory
activity against topoisomerase II at a concentration of 20 μM, with values of 65% and 97%, …

… Type II topoisomerases (TOP2s) resolve the topological … Several widely prescribed anticancer
drugs increase the … to DNA and to the anticancer drug etoposide to reveal structural details …

… Topoisomerase II inhibitors will interfere with the breakage-rejoining reaction thereby … of
our compounds to inhibit topoisomerase II enzymatic activity, we used a topoisomerase-II drug …

… Clinically used topoisomerase II (TOP2) inhibitors are poison inhibitors that induce DNA …
TOP2 inhibitors with a different mechanism of action (MOA), such as catalytic TOP2 inhibitors, …

Full article: Investigating the potential anticancer activities of antibiotics as topoisomerase II
inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR …

… Observing the results of biological tests, we can conclude that a strong relationship exists
between the anticancer activity, Topo II inhibition and DNA binding activity of the tested …

… inhibition and pro-apoptotic activity. Also, thiazolopyrimidine 3d showed potent topoisomerase
II inhibitory activity … the binding site of topoisomerase II enzyme rationalizing the significant …

… topoisomerase II poisons are used solely for their antitumor activities, catalytic inhibitors
are … as well as to a general lack of antitumor activity (E. Sausville, personal communication). …

… protein kinase C activity and bacterial topoisomerase II activity, are significantly inhibited by
Cp … In order to further clarify the mechanism of antitumor action of the metallocene dihalides, …