… anticancer drugs are more prone to be found in the surface waters. In this study the consumption
of anticancer drugs … estimate the concentrations that can be expected in surface waters. …

… concentration ratio of a concentration at various time points within the dosing interval versus
the population median concentration … accurate and precise individual predictions as well as …

… drug concentrations to show how the predicted drug concentrations might be used to select
drug-… It is believed that this modeling strategy can be used as an aid in the drug development …

… This study presents the occurrence and impact of 78 anticancer drugs in Spanish river … of
the predicted environmental concentrations (PEC). The total consumption of anticancer drugs in …

… concentrations and the predicted concentration–time curve; (ii) estimation of several
pharmacokinetic parameter values and exposure indices simultaneously; (iii) flexibility with respect …

… anticancer drugs in Catalonia (NE Spain) during the period of 2013–2017 and calculates the
predicted environmental concentrations … can determine the evolution of drugs present in the …

… In some cases, these drug concentrations were several orders of magnitude greater than
concentrations needed to inhibit the desired targets of the drug. The use of such high …

… At first glance, the processes of anticancer drug development and environmental risk …
plasma drug concentrations), it can be seen from these data that the plasma concentrations of the …

… study, concentrations of total Pt between a few tens and in excess of 100 pg L − 1 are predicted,
… Although predicted concentrations are below EMEA guidelines warranting further risk …

… the therapeutic concentration range of anticancer drugs approaches the toxic concentration
… (I) proposed a noteworthy concept of predicting the MTD of anticancer drugs in humans, that …