Design, efficient synthesis, docking studies, and anticancer evaluation of new quinoxalines as potential intercalative Topo II inhibitors and apoptosis inducers

EM Abbass, AK Khalil, MM Mohamed, IH Eissa… - Bioorganic …, 2020 - Elsevier
As an extension for our earlier effort in the field of discovery of anticancer agents acting on
DNA and Topo II, eighteen quinoxaline derivatives were designed and synthesized. Such …

Synthesis and in vitro antitumor evaluation of betulin acid ester derivatives as novel apoptosis inducers

SJ Yang, MC Liu, HM Xiang, Q Zhao, W Xue… - European Journal of …, 2015 - Elsevier
… developing more potential anticancer drugs, in the present study nineteen BE derivatives
modified at C-3 and C-28 positions were designed and synthesized. The antitumor activities of …

Development of pyridazine derivatives as potential EGFR inhibitors and apoptosis inducers: Design, synthesis, anticancer evaluation, and molecular modeling studies

MF Ahmed, EY Santali, EMM El-Deen, IA Naguib… - Bioorganic …, 2021 - Elsevier
… cell cycle progression, apoptotic induction and gene regulation … Moreover, the apoptotic
induction of UO-31 renal cancer … be considered as effective apoptosis modulators and promising …

Design, synthesis, anticancer evaluation, and molecular modelling studies of novel tolmetin derivatives as potential VEGFR-2 inhibitors and apoptosis inducers

AE Kassab, EM Gedawy, MIA Hamed… - Journal of enzyme …, 2021 - Taylor & Francis
… of efficient anticancer agents that exhibited different enzymatic and cellular targets such
as apoptosis induction in different human cancer cell lines and inhibition of VEGFR-2. …

Design, synthesis, molecular docking and biological activity evaluation of some novel indole derivatives as potent anticancer active agents and apoptosis inducers

AMS El-Sharief, YA Ammar, A Belal… - Bioorganic …, 2019 - Elsevier
apoptosis induction ability of the new promising anticancer … Measuring cell cycle arrest and
induction of apoptosis in … of cancer cells and induction of apoptosis was performed. Thus, we …

[HTML][HTML] Herbal medicine as inducers of apoptosis in cancer treatment

E Safarzadeh, SS Shotorbani… - Advanced …, 2014 - ncbi.nlm.nih.gov
Induction of apoptosis is one of the most important markers of cytotoxic antitumor agents.
Some natural compounds including plants induce apoptotic pathways that are blocked in …

Discovery of 4-aryl-4H-chromenes as potent apoptosis inducers using a cell-and caspase-based Anti-cancer Screening Apoptosis Program (ASAP): SAR studies and …

SX Cai, J Drewe, W Kemnitzer - Anti-Cancer Agents in …, 2009 - ingentaconnect.com
apoptosis inducers as potential anticancer agents [13] via developing a cell- and caspase-based
Anti-cancer Screening Apoptosis Program (ASAP) HTS assay for apoptosis inducers

Biology and medicinal chemistry approaches towards various apoptosis inducers

VK Vyas, C Chintha… - Anti-Cancer Agents in …, 2013 - ingentaconnect.com
… of ASAP in filtering the compounds having apoptosis inducing activity [62]. … review
focuses on the literature pertaining to apoptosis inducers as potential vascular disrupting (anticancer) …

Synthesis, structure–activity relationships and preliminary antitumor evaluation of benzothiazole-2-thiol derivatives as novel apoptosis inducers

Z Wang, XH Shi, J Wang, T Zhou, YZ Xu… - Bioorganic & medicinal …, 2011 - Elsevier
… To develop novel tumor growth inhibitors and apoptosis inducers as potential anticancer
agents, we designed and synthesized a series of benzothiazole-2-thiol derivatives, based on …

Synthesis and in vitro evaluation of substituted quinolines as new apoptosis inducers and anticancer agents: Pharmacophore-based design

H Dayani, A Jha, M Ghate… - Letters in Drug Design & …, 2021 - ingentaconnect.com
apoptosis inducers as anticancer agents, we performed ligand-based pharmacophore
modeling with known apoptosis inducers as anticancer … Known apoptosis inducers with diverse …