[HTML][HTML] Augmenting azoles with drug synergy to expand the antifungal toolbox

A Kane, DA Carter - Pharmaceuticals, 2022 - mdpi.com
antifungal arsenal. Recent research has focused on improving azoles, our most successful
class of antifungals, by looking for synergisticSynergy can successfully widen the antifungal

[HTML][HTML] Novel combinations of agents targeting translation that synergistically inhibit fungal pathogens

C Vallières, R Raulo, M Dickinson… - Frontiers in microbiology, 2018 - frontiersin.org
… molecular toolbox. Such advantages have been applied to characterize mechanisms of …
-derived antimalarial drugs. We hypothesized that antifungal synergy with bicarbonate or …

The antifungal pipeline: a reality check

JR Perfect - Nature reviews Drug discovery, 2017 - nature.com
… Second, the diagnostic toolbox for fungal infections has been substantially improved and …
activity, and can be additive or synergistic with other antifungal agents, such as the azoles or …

[HTML][HTML] Sources of antifungal drugs

G Vanreppelen, J Wuyts, P Van Dijck, P Vandecruys - Journal of Fungi, 2023 - mdpi.com
… It showed promising synergy with the established antifungal drugs fluconazole, caspofungin…
space, and eventually, expand the antifungal toolbox. Aside from expanding the chemical …

Spectrum of activity and mechanisms of azole–bisphosphonate synergy in pathogenic Candida

A Kane, H Dinh, L Campbell, AK Cain… - Microbiology …, 2024 - Am Soc Microbiol
… Azole antifungals are an important part of the clinical toolbox … Due to the increasing emergence
of drug-resistant cases of … synergy in Cryptococcus by applying these drug combinations …

Novel combinations of agents targeting translation that synergistically inhibit fungal pathogens

R Raulo, M Dickinson, SV Avery - Frontiers in … - nottingham-repository.worktribe.com
… molecular toolbox. Such advantages have been applied to characterize mechanisms of …
-derived antimalarial drugs. We hypothesized that antifungal synergy with bicarbonate or …

A search for novel synergistic combinations against prevalent fungal phytopathogens

T Young - eprints.nottingham.ac.uk
… this synergy was investigated, initially testing for synergistic … most likely involves the
synergistic increase of oxidative damage … The specific action of cyprodinil in the synergy remains …

Bisphosphonates synergistically enhance the antifungal activity of azoles in dermatophytes and other pathogenic molds

A Kane, JG Rothwell, A Guttentag, S Hainsworth… - Msphere, 2024 - Am Soc Microbiol
… a vital part of the clinical antifungal toolbox, and fluconazole, … (11), and using drug synergy
to improve the activity of azoles … We investigated synergy between ZOL and azole antifungals

[HTML][HTML] Joining forces: Leveraging novel combination therapies to combat infections with eukaryotic pathogens

RE Ham, LA Temesvari - PLoS Pathogens, 2020 - journals.plos.org
… of drugs for the same individual effects, and synergistic interactions require decreased dosage
of drugs … Fluconazole, a broad-spectrum antifungal, inhibits ergosterol synthesis; this drug

Baker's yeast as a tool for the development of antifungal drugs which target cell integrity–an update

JJ Heinisch - Expert Opinion on Drug Discovery, 2008 - Taylor & Francis
… specific inhibitors may serve as an alternative in synergistic drug treatments, as pmt mutants
have been shown to be more susceptible to other antifungals (see for further references). …