Safety and immunogenicity of a five-component acellular pertussis vaccine with varying antigen quantities

SA Halperin, L Barreto, BJ Eastwood… - … of pediatrics & …, 1994 - jamanetwork.com
… No in¬ creased adverse effects were demonstrated with in¬ creased antigen content in the
acellular vaccine formu¬ lations. The APV formulation is currently part of the second efficacy …

Cell-mediated and antibody responses to Bordetella pertussis antigens in children vaccinated with acellular or whole-cell pertussis vaccines

A Cassone, CM Ausiello, F Urbani… - … of pediatrics & …, 1997 - jamanetwork.com
… B pertussis antigens (pertussis toxin, filamentous hemagglutinin, and pertactin). Antibody titers
against pertussis … Results: A CMI-positive response to at least 1 B pertussis antigen at 1 or …

Decennial administration of a reduced antigen content diphtheria and tetanus toxoids and acellular pertussis vaccine in young adults

J Mertsola, O Van Der Meeren, Q He… - Clinical infectious …, 2010 - academic.oup.com
… populations against pertussis is generally achieved through administration of a single dose
of reduced antigen content combined diphtheria and tetanus toxoids and acellular pertussis (…

Development of acellular pertussis vaccines

Y Sato, H Sato - Biologicals, 1999 - Elsevier
… that PTd was the essential antigen in the acellular pertussis vaccine but that fFHA … content
in the vaccine may be reduced by adding fFHA to get the same ED50, but total protein content

Outer membrane vesicles as acellular vaccine against pertussis

R Roberts, G Moreno, D Bottero, ME Gaillard… - Vaccine, 2008 - Elsevier
… immunogens in OMVs together with a variety of putatively important antigens. The structure
antigens, each of which may be insufficient to confer immunity when administered alone. …

Immunogenicity and reactogenicity of acellular pertussis booster vaccines in children: standard pediatric versus a reduced-antigen content formulation

CU Meyer, P Habermehl, M Knuf, B Hoet… - Human …, 2008 - Taylor & Francis
… reduced antigen content diphtheria-tetanus-acellular pertussis vaccine (dTpa) administered
as a booster to 4-6 year-old children primed with four doses of whole-cell pertussis vaccine. …

A decennial booster dose of reduced antigen content diphtheria, tetanus, acellular pertussis vaccine (Boostrix™) is immunogenic and well tolerated in adults

R Booy, O Van Der Meeren, SP Ng, F Celzo… - Vaccine, 2010 - Elsevier
… To our knowledge, this is the first study exploring the feasibility of repeated decennial booster
vaccination with reduced-antigen-content acellular pertussis vaccines in adults. The adults …

Dose-response to acellular pertussis vaccine and comparison with whole cell pertussis vaccine at 15–24 months and 4–6 years of age

…, NA Halsey, Acellular Pertussis Vaccine Study team - Vaccine, 1992 - Elsevier
… In order to address the issue of optimal antigen content of acellular pertussisacellular DTP
vaccine in two dosage regimens in children 15-24 months and 4-6 years of age. The acellular

Overview of recent clinical trials of acellular pertussis vaccines

E Miller - Biologicals, 1999 - Elsevier
… #icacy of acellular pertussis vaccines. The reactogenicity and immunogenicity results of the
various Phase II trials in which acellular vaccines with widely di#erent antigen contents have …

High levels of antibody in adults three years after vaccination with a reduced antigen content diphtheria-tetanus-acellular pertussis vaccine

PB McIntyre, FM Turnbull, AM Egan, MA Burgess… - Vaccine, 2004 - Elsevier
… reactogenicity of whole-cell pertussis vaccines when administered beyond childhood. …
acellular pertussis vaccines with reduced antigen content has seen calls for widespread pertussis