… T cells, understanding how the properties of memory CD8 T cells are affected by
additional Ag exposures is necessary. Furthermore, the effects of time on the properties of …

… Thus, repeated antigen stimulation shapes memory CD8 + T cell populations to either
enhance or decrease per cell protective immunity in a pathogen-specific manner, a concept of …

… within the antigen-specific memory CD8 T cell compartment and classifications of memory
CD8 T … Importantly, although Ag-exposure history defines CD8 T cell dynamics and protection …

… that can discriminate between memory CD8 T-cell populations specific to viruses that are
efficiently cleared, such as influenza virus, and to those (predominantly effector CD8 T-cell …

… lived memory CD8 T cells specific for a single vaccine antigen as there were memory CD8 T
… Repeated exposure to pathogens and the generation of memory CD8 + T cells tasked to kill …

… The impact of repeated Ag exposure on memory CD8 T cell differentiation was … Ag exposures
dictates important phenotypic and functional characteristics of the resulting memory CD8 T …

… In conclusion, we have shown how time after initial Ag-encounter and Ag-exposure history
can impact regulation of bystander CD8 T cell effector functions. While Ag-dependent effector …

… Our results show that naïve CD8 cells, exposed to reduced duration or concentration of
antigen during viral infection convert into memory more efficiently, an observation that could have …

… exposure to antigen during chronic LCMV infection do not acquire the cardinal properties
of memory CD8 T cells, including antigen-… exposure to antigen without rest results in CD8 T …

… antigen exposure induces memory CD8 T cell responses of a superior magnitude relative
to memory … However, in spite of substantially lower numbers of memory CD8 T cells in all …