HCC-derived exosomes: critical player and target for cancer immune escape

Q Han, H Zhao, Y Jiang, C Yin, J Zhang - Cells, 2019 - mdpi.com
… It is possible that HCC exosomes also carry HCC-specific antigens that can trigger a strong
DC-mediated immune response, and make the tumor microenvironment more conducive to …

Immunobiology of hepatocellular carcinoma

T Flecken, HC Spangenberg, R Thimme - Langenbeck's archives of …, 2012 - Springer
… and antibodies in general in the natural immune response … In most patients, HCC-specific
immune responses fail to … due to the fact that HCC evades the immune response. The growing …

Immune checkpoint blockade in hepatocellular carcinoma

M Kudo - Liver Cancer, 2015 - karger.com
… -associated antigens are recognized and presented by antigen presenting cells … immune
response, allowing the tumor to escape from the attack of CTLs (immune escape or immune

Tumor immune microenvironment and immunosuppressive therapy in hepatocellular carcinoma: a review

K Oura, A Morishita, J Tani, T Masaki - International journal of molecular …, 2021 - mdpi.com
immune TME of HCC and immunosuppressive approaches focused on monoclonal antibodies
… are impaired in HCC to elucidate an effective cancer immune response and to contribute …

[HTML][HTML] Autoantibodies against tumor-associated antigens for detection of hepatocellular carcinoma

Y Hong, J Huang - World Journal of Hepatology, 2015 - ncbi.nlm.nih.gov
HCC, and reliable tools for early diagnosis are lacking. Therefore, novel biomarkers for
the early detection of HCC … humoral immune responses to self-antigens called tumor-associated …

Immunotherapy for hepatocellular carcinoma

S Li, F Yang, X Ren - Drug discoveries & therapeutics, 2015 - jstage.jst.go.jp
antigens expressed by tumor cells and normal proteins is small, or the antigens have low
antigenicity, sufficient immune response will … (AFP) is an antigen associated with HCC, which …

Immune checkpoint inhibitors in the treatment of HCC

C Donisi, M Puzzoni, P Ziranu, E Lai, S Mariani… - Frontiers in …, 2021 - frontiersin.org
… PD1) antibodies and the anti-Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) antibodies have
been … , reduces Treg activity, and leads to the reactivation of the anticancer immune response. …

[HTML][HTML] Immunotherapeutic approaches for hepatocellular carcinoma

V Longo, A Gnoni, AC Gardini, S Pisconti, A Licchetta… - Oncotarget, 2017 - ncbi.nlm.nih.gov
… Recent studies focus on the role of immune system in HCC. In fact, the unique immune response
… Spontaneous immune responses against tumor antigens have been detected, and new …

Viral determinants and host immune responses in the pathogenesis of HBV infection

M Rapicetta, C Ferrari, M Levrero - Journal of medical virology, 2002 - Wiley Online Library
… the healthy carrier state, cirrhosis and hepatocellular carcinoma (HCC). The outcome of …
antigen specific immune responses by affecting the processing and presentation of viral antigens

Analysis of CD4+ T-Cell Responses to a Novel α-Fetoprotein-Derived Epitope in Hepatocellular Carcinoma Patients

A Alisa, A Ives, AA Pathan, CV Navarrete… - Clinical cancer …, 2005 - AACR
… the existence of immune responses to antigens expressed by … , this naturally occurring
antitumor immune response fails to … antigen in the induction of specific CD4 + T-cell responses in …