… The genes encoding antigen receptors are unique because of their high diversity and their
assembly in developing lymphocytes from gene … and T-cell receptor gene segments is tightly …

… is that the TCR a gene greatly exceeds 8 (or any other antigen receptor gene) in the large
(> 50) number of J region segments". Two D and two J gene segments are evident in TCR 8". …

Two specialized forms of site-directed double-strand (ds) DNA breakage and rejoining are
part of the physiologic program of lymphocytes. One is recombination of the V, D and J gene …

… genes possess variants of the YYC/YFC motif (eg, some mammalian TCRβ genes and the
nurse shark antigen receptor [NAR]; … A new antigen receptor gene family that undergoes …

… Analysis of mice carrying mutant T-cell antigen receptor (TCR) genes indicates that TCR-(8
gene … of a large variety of antigens is achieved by antigen-specific lymphocyte receptors, the …

… by antigen. The combination of all of these sources of diversity creates the vast repertoire
of antigen receptor and antibody specificities from a relatively limited number of genes. …

… Antigen receptor genes exist in the germline in a “split” configuration and are assembled in
… This review discusses the structure of antigen receptor genes and the mechanisms by which …

… this molecule new or nurse shark antigen receptor (NAR). A … sharks use other antigen receptors
besides immunoglobulin and … Our data suggest that additional antigen receptors may be …

… V(D)J recombination is required not only for receptor … sequences flanking all antigen receptor
gene segments that function … of antigen receptor loci by rendering certain gene segments …

… antigen receptor is a heterodimeric molecule composed of a- and fl-subunits of relative
molecular mass 40,000-S0,OOO (refs 1-6). Recently, the genes … the T-cell antigen receptor do not …