… One of the most advanced technologies is chimeric antigen receptor (CAR) T-cell therapy,
a … In addition, new solutions have been proposed to overcome the limitations of this therapy. …

… This review discusses these barriers and proposes some potential solutions to improving …
We propose a call to action for key stakeholder groups to address these barriers to CAR-T …

… thus the impact of the proposed solutions can vary based on the relative magnitude of a
given barrier. Further, most of the proposed solutions will necessarily involve committing time …

… We review the many factors that lead to the high cost of CAR T-cells and offer proposals for
… Chimeric antigen receptor (CAR) T-cells are a type of cellular immunotherapy created by …

… Chimeric antigen receptors (CAR) are recombinant receptors that provide both antigen-…
, targeting an array of cell surface tumor antigens. Their biologic functions have dramatically …

… The concept of adoptive T cell therapeutics was introduced more than three decades ago,
when the idea of chimeric antigen receptor- … We propose practical recommendations for 2024. …

… This immobilized phase is then exposed to a solution phase of a test ligand. As the ligand-receptor
interaction occurs, the solution phase ligand is concentrated in the zone probed by …

… Thus, a different structural solution is usedto maintain stability in the Vβ8.2 CDR1 to that found
… This would be compatible with proposed TCR/MHC/peptide models where thenecessity of …

… methods have been proposed. One such approach engineers T cells to express a cytokine
… An alternative to achieve a more physiological solution to this problem has been to graft the …

… membrane structure proposed several … solution the peptide contains only a small percentage
of α helical and about 75% random coil structures, while CP in a hydrophobic solution (…