Impact of scFv structure in chimeric antigen receptor on receptor expression efficiency and antigen recognition properties

K Fujiwara, M Masutani, M Tachibana… - … and biophysical research …, 2020 - Elsevier
… expressing chimeric antigen receptor (CAR… antigen specificity and reactivity of CAR-T cells
are defined by CAR expression level and affinity, information on optimizing the scFv structure

[HTML][HTML] The three‐dimensional structure of a T‐cell antigen receptor VαVβ heterodimer reveals a novel arrangement of the Vβ domain

D Housset, G Mazza, C Grégoire, C Piras… - The EMBO …, 1997 - embopress.org
… The crystal structure of a mouse T‐cell antigen receptor (TCR) Fv fragment complexed to the
Fab fragment of a specific anti‐clonotypic antibody has been determined to 2.6 Å resolution. …

Structural analysis of mouse S-antigen

M Tsuda, M Syed, K Bugra, JP Whelan, JF McGinnis… - Gene, 1988 - Elsevier
… The knowledge ofthe primary structure of mouse S-antigen may help us in understanding
general and specific mechanisms of autoimmunity as well as the function of S-antigen in …

Structural and functional studies of Igαβ and its assembly with the B cell antigen receptor

S Radaev, Z Zou, P Tolar, K Nguyen, AT Nguyen… - Structure, 2010 - cell.com
… isotypes of the B cell receptors, and identified, through mutational analysis, residues on the
… the receptor and coreceptor association. Together, these studies provide the first structural

Molecular analysis of the antigen receptor of virus‐specific cytotoxic T cells and identification of a new Vα family

H Pircher, EE Michalopoulos, A Iwamoto… - European journal of …, 1987 - Wiley Online Library
… the primary structure of the a@-antigen receptor of a lymphocytic choriomeningitis virus (LCMV)-specific
cytotoxic T cell clone (P14). The fi chain of the T cell receptor is composed of …

Signal transduction by T-and B-cell antigen receptors: converging structures and concepts

JC Cambier - Current opinion in immunology, 1992 - Elsevier
… mic domains of the antigen receptor complex. However, … antigen receptors, like B-cell antigen
receptors, are extended multimeric complexes composed of disulfidelinked dimeric antigen

Structure of the T cell antigen receptor (TCR): two CD3 epsilon subunits in a functional TCR/CD3 complex.

A de la Hera, U Müller, C Olsson, S Isaaz… - The Journal of …, 1991 - rupress.org
… In summary, after the analysis of >100 individuals from five different transgenic lines from …
quent generation of h/m chimeric antigen receptors does not disrupt normal T cell development …

The structure of the T cell antigen receptor genes in normal and malignant T cells

MD Minden, TW Mak - 1986 - ashpublications.org
… In this review the genomic structure and the RNA transcripts of the alpha and beta chain
of the T cell antigen receptor have been discussed. Studies of the structure of TcR beta in …

ANARCI: antigen receptor numbering and receptor classification

J Dunbar, CM Deane - Bioinformatics, 2016 - academic.oup.com
… We have developed ANARCI, a program for annotating antigen receptor variable domain
amino-acid sequences with five commonly used numbering schemes. The program can be run …

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

SS Pang, R Berry, Z Chen, L Kjer-Nielsen, MA Perugini… - Nature, 2010 - nature.com
… There were three pre-TCR complexes in the asymmetric unit, all of which were highly
similar to each other, and structural analyses were thus confined to one pre-TCR complex. The …