Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion
… Our structural analysis showed that a network of interactions with HLA framework residues
was critical for 10LH complex formation. Thus, sequence divergence of HLA allotypes from …
was critical for 10LH complex formation. Thus, sequence divergence of HLA allotypes from …
Functional analysis of Csk in signal transduction through the B-cell antigen receptor
… ligand to antigen-specific surface receptors. The stimulation of these receptors triggers a …
of the B-cell antigen receptor (BCR) with anti-BCR antibodies to induce a rapid elevation of …
of the B-cell antigen receptor (BCR) with anti-BCR antibodies to induce a rapid elevation of …
The Murine T-Cell Antigen: Ia Receptor: Functional and Structural Analysis with a Monoclonal Antireceptor Antibody
J Kaye - Hybridoma Technology in the Biosciences and …, 1985 - Springer
… Thus far, antibodies against antigen receptor determinants shared between T cells have …
cell surface receptors. In the case of T-cell activation, where the antigen receptor interacts with a …
cell surface receptors. In the case of T-cell activation, where the antigen receptor interacts with a …
The T-cell antigen receptor: a multisubunit signaling complex
AM Weissman - Lymphocyte Activation, 1994 - karger.com
… that there are two CD3- subunits per receptor [38-40], Additional … of receptor structure is
complicated by co-immunoprecipitation studies using anti-8 and anti- reagents, in which receptor …
complicated by co-immunoprecipitation studies using anti-8 and anti- reagents, in which receptor …
Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain.
… associated with hematopoietic cell antigen receptors. Here, we characterize signaling by
a 17 amino acid motif that is triplicated in the T cell antigen receptor ~" chain. Analysis of ~" …
a 17 amino acid motif that is triplicated in the T cell antigen receptor ~" chain. Analysis of ~" …
T cell and B cell antigen receptors share a conserved core transmembrane structure
… stabilizing role in the assembled receptor. A TM helix–… receptors throughout evolution,
pointing to a previously unappreciated level of TM structural conservation in antigen receptors and …
pointing to a previously unappreciated level of TM structural conservation in antigen receptors and …
T-cell antigen receptor-alpha chain transmembrane peptides: Correlation between structure and function
… from the transmembrane sequence of T cell antigen receptor (TCR)-alpha chain that is …
of CP analogues and correlated their model structure with their biological activity. It became …
of CP analogues and correlated their model structure with their biological activity. It became …
Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia
BT Messmer, E Albesiano, DG Efremov… - The Journal of …, 2004 - rupress.org
… antigen receptors (BCRs) arising from the use of common H and L chain V region gene
segments that share CDR3 structural … Thus, a much more striking degree of structural restriction …
segments that share CDR3 structural … Thus, a much more striking degree of structural restriction …
Structure of the complex between human T-cell receptor, viral peptide and HLA-A2
DN Garboczi, P Ghosh, U Utz, QR Fan, WE Biddison… - Nature, 1996 - nature.com
… antigen receptor (TCR) of peptide complexed with a major histocompatibility complex (MHC)
molecule occurs through variable loops in the TCR structure … of an antigenic peptide bound …
molecule occurs through variable loops in the TCR structure … of an antigenic peptide bound …
Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor
LE Samelson, MD Patel, AM Weissman, JB Harford… - Cell, 1986 - cell.com
… extends our analysis of the phosphorylation events that occur in the T cell antigen receptor
complex upon antigen activation. We demonstrate that, although antigen and PMA result in …
complex upon antigen activation. We demonstrate that, although antigen and PMA result in …