… of MHC class II molecules is to bind peptides derived from antigens that access the endocytic
route of antigen … Formation of the MHC II–peptide complexes entails the confluence of the …

… In order to define the actual peptides that are presented on … peptides bound intracellularly
by MHC class I molecules 7. With such a procedure, the naturally processed antigenic peptide …

… encoded in the MHC, are involved. After binding peptides, class II molecules are transported
… where their primary function of presenting antigenic peptides to CD4 + T cells is carried out. …

… MHC class I molecule, HLA-A2.- This analysis revealed the class I MHC molecule to be
composed of two … At the membrane-proximal end, the a3 domain ofthe MHC-encoded, 44 kDa …

… understanding of peptide binding by MHC class I molecules. … tides associated with MHC
class II molecules, largely because … recognition of peptide antigens by MHC class I molecules. …

… class II alleles has allowed a general statement to be made of the principles of peptide binding
in the case of MHC class II molecules. … segment that blocks antigen-binding to HLA-DR1 …

… This assumption turned out to be wrong, and a number of genes encodingproteins involved
in antigen processing for MHC class I molecules, as well asthe genes encoding DM, have …

… system in a manner that might better reflect naturally occurring antigen … class II molecules
contain peptide sequences that are capable of binding to their own class II or other class II …

… dissociation rate of each peptide from MHC class I at 37C and … immunogenic peptides formed
relatively stable MHC-peptide … the antigenicity of surface class I MHC molecules from the …

… of peptide binding groove. We investigated the molecular mechanisms for MHC class I-peptide …
class I molecule H-2Kb complexed with either VSV-8 peptide [vesicular stomatitis virus …