Antimicrobial activity and structure of a consensus human βdefensin and its comparison to a novel putative hBD10

…, E Villegas, B Rivas‐Santiago… - Proteins: Structure …, 2020 - Wiley Online Library
… novel antimicrobial peptides from the human β-defensin … They showed antimicrobial activity
against Escherichia coli, … that it adopts a classical β-defensin fold and disulfide connectivities. …

Structure-activity relationships in defensin dimers: a novel link between β-defensin tertiary structure and antimicrobial activity

DJ Campopiano, DJ Clarke, NC Polfer… - Journal of Biological …, 2004 - ASBMB
antimicrobial activity of the five cysteine-containing defensin, we used high resolution FT-ICR
mass spectrometry. The resolving power and accuracy of this instrument allows the …

Antibacterial activity and specificity of the six human α-defensins

B Ericksen, Z Wu, W Lu, RI Lehrer - Antimicrobial agents and …, 2005 - Am Soc Microbiol
… cereus, which was highly susceptible to the other five α-defensins. The … antimicrobial
activities of host-defense peptides. Its use has clarified the relative potencies of human α-defensins

Broad-spectrum antimicrobial activity of human intestinal defensin 5

EM Porter, E van Dam, EV Valore… - Infection and immunity, 1997 - Am Soc Microbiol
… This study explored the antimicrobial activity of human intestinal defensin under various
conditions that could be encountered in the small intestinal milieu. rHD-5 was active at low …

Porcine β-defensin 2 displays broad antimicrobial activity against pathogenic intestinal bacteria

EJA Veldhuizen, M Rijnders, EA Claassen… - Molecular …, 2008 - Elsevier
Defensins are small antimicrobial peptides that play an important role in the innate immune
… describe the antimicrobial activity of pBD-2, a recently discovered new porcine defensin that …

Antimicrobial activity, mechanism of action, and methods for stabilisation of defensins as new therapeutic agents

M Amerikova, I Pencheva El-Tibi… - Biotechnology & …, 2019 - Taylor & Francis
… to analyse current applications of defensins as antimicrobial agents and their mechanism
of action. Moreover, new technologies and methods for stabilizing defensins are discussed. …

Antimicrobial characterization of human β-defensin 3 derivatives

DM Hoover, Z Wu, K Tucker, W Lu… - Antimicrobial agents …, 2003 - Am Soc Microbiol
… The findings that the disulfides of hBD3 are irrelevant for antimicrobial activity under the
conditions in the present study and that shorter peptides derived from the native sequence have …

Identification of a novel, multifunctional β-defensin (human β-defensin 3) with specific antimicrobial activity: Its interaction with plasma membranes of Xenopus …

JR García, F Jaumann, S Schulz, A Krause… - Cell and tissue …, 2001 - Springer
… of a third human β-defensin, called human β-defensin 3 (hBD-… Synthetic hBD-3 exhibits a
strong antimicrobial activity against … We describe a specific and relevant antimicrobial activity of …

Antimicrobial activities of human β-defensins against Bacillus species

P Yadava, C Zhang, J Sun, JA Hughes - … journal of antimicrobial agents, 2006 - Elsevier
… There has been little work comparing specific peptides as potential antimicrobial compounds.
In this study, we evaluated the antimicrobial activity of peptides from the human β-defensin

Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1

BO Schroeder, Z Wu, S Nuding, S Groscurth… - Nature, 2011 - nature.com
… observations we propose that antimicrobial activity of hBD-1 … agent DTT we compared the
antimicrobial activity of oxhBD-1 … coli K12 we found antimicrobial activity of both oxhBD-1 and …