Improving recognition of antimicrobial peptides and target selectivity through machine learning and genetic programming

D Veltri, U Kamath, A Shehu - IEEE/ACM transactions on …, 2015 - ieeexplore.ieee.org
… evolutionary algorithm (EA) based on Genetic Programming to explore the potentially vast
space … We note that EAs based on Genetic Programming, such as the EFC algorithm proposed …

Combining genetic algorithm with machine learning strategies for designing potent antimicrobial peptides

K Boone, C Wisdom, K Camarda, P Spencer… - BMC …, 2021 - Springer
… of CAMD antimicrobial peptide design [47]. Here, we describe our solution to the reverse
problem of CAMD antimicrobial peptide design with our Codon-Based Genetic Algorithm (CB-…

Computer-aided design of antimicrobial peptides: are we generating effective drug candidates?

MH Cardoso, RQ Orozco, SB Rezende… - Frontiers in …, 2020 - frontiersin.org
Antimicrobial peptides feature diverse structural conformations to display antimicrobial
activities (Cardoso et al., 2018c). Previous works have reported the clustering of AMPs according …

Molecular design and genetic optimization of antimicrobial peptides containing unnatural amino acids against antibiotic‐resistant bacterial infections

Y He, X He - Peptide Science, 2016 - Wiley Online Library
Antimicrobial peptides (AMPs) have been the focus of intense research towards the
finding of a viable alternative to current small-molecule antibiotics, owing to their commonly …

Optimization of antibacterial peptides by genetic algorithms and cheminformatics

CD Fjell, H Jenssen, WA Cheung… - Chemical biology & …, 2011 - Wiley Online Library
… life that possess antimicrobial activity by various mechanisms (2). These peptides have drawn
… While antimicrobial peptides generally exhibit lower potency against susceptible bacterial …

The value of antimicrobial peptides in the age of resistance

M Magana, M Pushpanathan, AL Santos… - The lancet infectious …, 2020 - thelancet.com
antimicrobial peptides as novel therapeutics. This Review identifies the benefits, challenges,
and opportunities of using antimicrobial peptides … of novel promising antimicrobial peptides, …

[HTML][HTML] An automatic representation of peptides for effective antimicrobial activity classification

JA Beltran, G Del Rio, CA Brizuela - Computational and structural …, 2020 - Elsevier
… Identifying these peptides will only be possible through the … identify candidates to antimicrobial
peptides before their biological … been used in previous antimicrobial peptide studies (see …

Engineering selectively targeting antimicrobial peptides

M Lei, A Jayaraman, JA Van Deventer… - Annual review of …, 2021 - annualreviews.org
… into AMPs and non-AMPs on the basis of their predicted antimicrobial activity. The authors …
peptide classification information in the second version of the Antimicrobial Peptide Database. …

[HTML][HTML] Creation of Recombinant Biocontrol Agents by Genetic Programming of Yeast

SO Pipiya, NZ Mirzoeva, MN Baranova, IE Eliseev… - Acta …, 2023 - ncbi.nlm.nih.gov
… This study focuses on the genetic programming of the methylotrophic yeast P. pastoris in …
agents, with antimicrobial peptide acting as the active component. A genetic construct ensuring …

Emerging computational approaches for antimicrobial peptide discovery

G Agüero-Chapin, D Galpert-Cañizares… - Antibiotics, 2022 - mdpi.com
… This worrying situation has encouraged the search of new antibiotics from antimicrobial
peptides (AMPs) with the ability to overcome resistance, mainly given by their versatile mode of …