… Antimicrobial host defense peptides (HDPs) are a critical … to ensure the antimicrobial potency
and target cell selectivity. With … peptides (HDPs; also known as antimicrobial peptides) have …

… exhibit broad antimicrobial spectra … selectivity (bacteria versus host cells) of AMPs and
various attempts to control it, including the optimization of physicochemical parameters of peptides…

… While antimicrobials with selective targeting capabilities are not limited to peptides (9, 10), …
focuses on studies that utilize peptides as targeting components to improve selectivity. In the …

… of the first synthetic, target-specific antimicrobial peptide, G10KHc, via addition of a … targeting
moiety (KH) to a generally killing peptide (novispirin G10). The resulting chimeric peptide …

… Moreover, this paper demonstrates for the first time the capability not only to recognize that
a peptide is an AMP or not but also to predict its target selectivity based on models of activity …

… The fact that most bacteria have a strong electrochemical gradient (Δψ) relative to
mammalian cells is also thought to increase target selectivity of antimicrobial peptides [9]. …

… Here comes the importance of development of highly selective antimicrobials, which kills
the targeted organism selectively and at the same time does not alter the prevalent microbial …

… for antimicrobial peptides (AMPs), short peptides produced by … of many AMPs is their cell
selectivity, ie, the ability to kill … devoted to understand and further improve AMP selectivity. …

… To develop Gram-negative selective compounds that can inhibit the effects of LPS-induced
sepsis, we have designed constrained cyclic antimicrobial peptides based on a cystine-…

… antimicrobial activities, which leads to hemolysis of the host cells (59). Thus, we need to
develop AMPs that show selective … target-selective AMPs and their potential as safe antibiotics. …