Metallo-β-lactamase-mediated antimicrobial resistance and progress in inhibitor discovery

Y Yang, YH Yan, CJ Schofield, A McNally, Z Zong… - Trends in …, 2023 - cell.com
… Here we review the classification, structures, substrate profiles, and inhibition mechanisms
of MBLs, highlighting current clinical problems due to MBL-mediated resistance and progress …

Antimicrobial resistance profile of Pseudomonas aeruginosa producing metallo-β-lactamases

VA Agarwal, SA Dongre, RM Powar - Indian Journal of Medical …, 2006 - journals.lww.com
… to perceived toxic side effects and availability of antimicrobials with better safety profiles. …
The susceptibility of these isolates to antipseudomonal antimicrobials was done by disc …

Molecular characterization and antimicrobial susceptibility profile of New Delhi metallo-beta-lactamase-1-producing Escherichia coli among hospitalized patients

A Agarwal, J Srivastava… - Journal of Laboratory …, 2018 - thieme-connect.com
Antimicrobial susceptibility profile of all the isolates showing carbapenemase production by
phenotypic method was determined by Kirby–Bauer disc diffusion method as per CLSI 2014 …

Metallo-β-lactamase resistance in Enterobacteriaceae is an artefact of currently utilized antimicrobial susceptibility testing methods

TE Asempa, K Abdelraouf… - Journal of Antimicrobial …, 2020 - academic.oup.com
… Results indicate that meropenem in vivo efficacy is best represented by the
pharmacodynamic profile generated using MICs determined in zinc-depleted media for MBL-producing …

[HTML][HTML] Novel combination of nanoparticles and metallo-β-lactamase inhibitor/antimicrobial-based formulation to combat antibiotic resistant Enterococcus sp. and …

NC Gómez, J Manetsberger, N Benomar… - International Journal of …, 2023 - Elsevier
… with metallo-β-lactamase inhibitor/antimicrobial-based formulation (EDTA/HLE) showed
antimicrobial … Microscopic analyses confirmed that the antimicrobial activity of nanoparticles was …

Identification of a series of tricyclic natural products as potent broad-spectrum inhibitors of metallo-β-lactamases

DJ Payne, JA Hueso-Rodríguez, H Boyd… - Antimicrobial agents …, 2002 - Am Soc Microbiol
metallo-β-lactamase inhibitor in combination with a β-lactam antibiotic. In this regard a range
of different non-β-… The inhibitors were tested in both a susceptibility profile, to determine if …

Molecular characterization of SPM-1, a novel metallo-β-lactamase isolated in Latin America: report from the SENTRY antimicrobial surveillance programme

MA Toleman, AM Simm, TA Murphy… - … of Antimicrobial …, 2002 - academic.oup.com
… A novel family of class B metallo-β-lactamases, the VIM family (… no reports of mobile
metallo-β-lactamases being reported … the same antimicrobial susceptibility profile was isolated …

Polypyridine ligands as potential metallo-β-lactamase inhibitors

L La Piana, V Viaggi, L Principe, S Di Bella… - Journal of inorganic …, 2021 - Elsevier
metallo-β-lactamase-producing bacteria. All synergistic interactions restored the antimicrobial
… a multidrug-resistant profile. They showed high MIC values for the majority of tested …

Determination of antibiotic resistance profile and frequency of metallo-beta-lactamases in Pseudomonas aeruginosa isolates

F Hemmati, R Sourouri Zanjani, F Haghi… - Journal of Zanjan …, 2014 - eprints.bmsu.ac.ir
… IMPS, VIMs and SPMs: the diversity of metalloβ-lactamases produces by carbapenem-…
the pattern of antimicrobial resistance and evaluation of IMP, SPM and SIM Metallo- Beta- …

[HTML][HTML] Antimicrobial Profile and Phenotypic Metallo-β-Lactamase Detection of Acinetobacter baumannii Isolated From Clinical and Environmental Specimens

H Salimizand, F Modarresi, O Azizi, S Mansouri… - Zahedan Journal of …, 2015 - zjrms.com
… In this study, antibiotic profile and phenotypic detection of A. baumannii isolates were
sought. Susceptibility testing showed high level of resistance in our clinical setting, especially …