… drugs, clothing, shelter, etc. Natural compounds have been extensively explored for new drug
discoveries … than half of the Food and Drug Administration (FDA) approved drugs [9]. In the …

… antimicrobial drug discovery with a special emphasis on the historical development of
antimicrobial … The revolution in the therapeutics discovery that was initiated by penicillin paved the …

… analogs of existing drugs and evaluate them for improved therapeutic activity and a broader
… the antimicrobial drug discovery process. Usually, antibacterial activity was discovered first …

… arena guarantees that there will be fewer therapeutic options in the future. Paradoxically, on
… equipped to discover new targets and pathways suitable for antimicrobial drug development…

… important antimicrobial targets would be missed by using as targets for drug discovery
only … We thank our colleagues at Genome Therapeutics Corporation and the Schering-Plough …

… , phytochemistry, ethnobotany and other biological fields for drug discovery. …
Antimicrobial and phytochemical studies on 45 Indian medicinal plants against multi-drug …

… As an example, efflux mechanisms are broadly recognized as major components of
resistance to many classes of chemotherapeutic agents as well as antimicrobial agents. Efflux …

… of new agents as the consensus became that fungal antimicrobials were often found to be
… as broad spectrum antimicrobials. These may represent attractive therapeutic agents in part …

… development of next-generation resistance-proof antimicrobials and would serve to decrease
antimicrobial stress at the global level and advance the field of antimicrobial therapeutics. …

… rifampicin poses a major problem restricting the available therapeutic choices. The
situation is further aggravated by the emergence of extensively drug-resistant tuberculosis (XDR-TB), …