… first dosage were used as the observed piperacillin values after the first piperacillin dose on
the second day of piperacillin dosing… The output from the dose optimization software was an …

Optimization of antibiotic dosing is a treatment intervention … the therapeutic exposure of steady
state piperacillin concentrations (… infusion of piperacillin with dosing personalized through …

… using TDM-guided antimicrobial therapy with dosing tailored to the … Therefore, we designed
a RCT using a TDM-based dose-… dose adaptation of β-lactam antibiotic therapy improves …

… However, there are no comprehensive data on the variability of antibiotic concentrations …
of dosing during an entire 7-day antibiotic course and to investigate the variability in antibiotic …

… Piperacillin therapy was initiated at a dosage of 200 to 300 mg/kg/day intravenously … a
dosage modified to maintain therapeutic serum concentrations. Concomitant antimicrobial therapy …

… on antibacterial activity and the emergence of piperacillin resistance following administration
of piperacillin-tazobactam by bolus versus extended infusion. Piperacillin administration by …

… dosing to critically ill patients with sepsis and (ii) to use population pharmacokinetics to
perform Monte Carlo dosing … (MIC) for different piperacillin dosing regimens against bacterial …

… if empirical dosing with piperacillin-tazobactam (4 g/0.5 g) given every 8 h (q8h) results in
therapeutic plasma concentrations in septic shock patients within the initial 24 h of therapy. A …

… Since clinical or bacteriological success was not the primary objective of the study,
evaluation of response to antibiotic treatment with piperacillin–tazobactam was mainly based on …

… As a time-dependent antibiotic, the bactericidal activity of piperacillin/tazobactam is optimized
… antimicrobial agents through research, it is evidenced that proper use of antimicrobials can …