Spectroscopic investigation on the binding of antineoplastic drug oxaliplatin to human serum albumin and molecular modeling

Y Yue, X Chen, J Qin, X Yao - Colloids and Surfaces B: Biointerfaces, 2009 - Elsevier
oxaliplatin with human serum albumin (… oxaliplatin with HSA was static quenching
mechanism. The value of 1.64 nm for the distance r between the donor (HSA) and acceptor (oxaliplatin

Human serum albumin interaction with oxaliplatin studied by capillary isoelectric focusing with the whole column imaging detection and spectroscopic method

T Lemma, J Pawliszyn - Journal of pharmaceutical and biomedical analysis, 2009 - Elsevier
… (WCID) was used to investigate drug-protein interactions. This study … anticancer drug,
oxaliplatin, with human serum albumin (HSA) in aqueous solution at physiological pH with drug

[HTML][HTML] … selectivity and improving drug release from mesoporous silica nanoparticles in the presence of human serum albumin in cisplatin, carboplatin, oxaliplatin …

ME Moghadam, M Sadeghi, H Mansouri-Torshizi… - European Journal of …, 2023 - Elsevier
anti-cancer agents, a carrier could be used to deliver a drug … of Pt anticancer complexes as
oxaliplatin in human plasma … In studies, the anti-cancer palladium drug, oxalipalladium, was …

Improvement of efficacy and decrement cytotoxicity of oxaliplatin anticancer drug using bovine serum albumin nanoparticles: synthesis, characterisation and release …

V Ziaaddini, M Saeidifar… - IET …, 2020 - Wiley Online Library
… homology with human serum albumin, … serum of bovine blood [11]. BSA nanoparticles (BSANPs)
are a suitable candidate for anticancer drugs to reduce the complications of anticancer

An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo

J Mayr, P Heffeter, D Groza, L Galvez… - Chemical …, 2017 - pubs.rsc.org
… is the use of human serum albumin (HSA) as a carrier. Abraxane®, 19,20 an albumin-bound …
to fully understand the impact of albumin-targeting on the biology of anticancer agents. …

Pt (IV) prodrugs designed to bind non-covalently to human serum albumin for drug delivery

YR Zheng, K Suntharalingam… - Journal of the …, 2014 - ACS Publications
… The FDA-approved platinum-based drugs cisplatin, carboplatin, and oxaliplatin are widely
… of anticancer drugs can be attributed to its nonimmunotoxicity, long circulation time in blood, …

Interaction of platinum agents, cisplatin, carboplatin and oxaliplatin against albumin in vivo rats and in vitro study using inductively coupled plasma‐mass …

R Kato, T Sato, A Iwamoto, T Yamazaki… - … & Drug Disposition, 2019 - Wiley Online Library
… Cisplatin is known to have the most potent anticancer effects, as well as serious side effects
… Cisplatin, carboplatin, oxaliplatin and bovine serum albumin were purchased from Sigma-…

Prolonged Release Evaluation of an Injectable Anticancer Drug using Human Serum Albumin Nanoparticle

F Rezaee, M Saeidifar, M Javaheri… - Biomacromolecular …, 2016 - bmmj.org
… of the large number of drug binding sites on the albumin molecule [5]. Interaction between
oxaliplatin as injectable anticancer drugs and human serum albumin was indicated that van …

Albumin-targeting of an oxaliplatin-releasing platinum (iv) prodrug results in pronounced anticancer activity due to endocytotic drug uptake in vivo

H Schueffl, S Theiner, G Hermann, J Mayr, P Fronik… - Chemical …, 2021 - pubs.rsc.org
Albumin is the most abundant plasma protein (35–50 g L −1 in human plasma) with an average
(plasmaOxaliplatin is one of the most efficient anticancer drugs against colorectal cancer …

… substrates for glucose transporters (GLUTs) and organic cation transporters (OCTs) exhibited cancer targeting and human serum albumin binding properties for drug …

J Ma, Q Wang, Z Huang, X Yang, Q Nie… - Journal of medicinal …, 2017 - ACS Publications
… (1a), oxaliplatin (3a), and satraplatin (5a). The presence of a hexadecanoic chain allowed
binding with human serum albumin (HSA) for drug … Platinum anticancer drug candidates are …